Efficacy of low-temperature plasma surgery for the treatment of OSAHS in children and its effects on inflammatory response, immune function, pain and sleep quality(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2025年第7期
- Page:
- 956-961
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Efficacy of low-temperature plasma surgery for the treatment of OSAHS in children and its effects on inflammatory response, immune function, pain and sleep quality
- Author(s):
- QIAO Ling; TANG Shihua; YAO Jiahao
- Department of Otorhinolaryngology, Head and Neck Surgery, Xinhua Hospital of Huainan Xinhua Medical Group, Huainan 232000,China
- Keywords:
- obstructive sleep apnea-hypopnea syndrome; children; low-temperature plasma surgery; inflammatory response; immune function; pain; sleep
- PACS:
- R318；R766
- DOI:
- DOI:10.3969/j.issn.1005-202X.2025.07.017
- Abstract:
- Abstract: Objective To analyze the therapeutic efficacy of low-temperature plasma surgery for children with obstructivesleep apnea-hypopnea syndrome (OSAHS) and its effects on inflammatory response, immune function, pain, and sleepquality for providing a basis for the rational treatment of OSAHS. Methods A prospective study was conducted on 92children with OSAHS from January 2021 to December 2023, and they were randomly divided into control group (n=46)and pilot group (n=46). Control group were given conventional tonsil and adenoidectomy, while observation group weregiven low-temperature plasma tonsil and adenoid ablation. These patients in both groups were followed-up for 6 months aftersurgery, and there was no lost case during the follow-up period. The two groups were compared for the efficacy at 6 monthsafter surgery, surgery-related indexes, scores of visual analogue scale for pain at 1, 2, and 3 days after surgery, sleep qualitybefore and at 6 months after surgery, inflammatory response, immune function, and the occurrence of complications duringthe 6 month follow-up period. Results Compared with control group, pilot group had higher overall effective rate at 6months postoperatively (93.48% vs 78.26%, P<0.05), less intraoperative bleeding, and shorter operation andhospitalization time (P<0.05). The visual analog scale score gradually decreased in both groups at 1, 2, 3 days postoperatively, and the scores were lower in pilot group than in control group (P<0.05). Compared with those before surgery,apnea hypoventilation index and respiratory disturbance index were lower in both groups at 6 months postoperatively, withlower indicator values in the pilot group (P<0.05); while the lowest blood oxygen saturation increased in the two groups, withhigher indicator values in the pilot group (P<0.05). Compared with those before surgery, serum procalcitonin, interleukin-1β,interleukin-6, high sensitive C-reactive protein, tumor necrosis factor-α, and whole-blood CD8+ were lower in both groups at3 days postoperatively, with lower indicator values in pilot group (P<0.05); while whole-blood CD3+ , CD4+ , CD4+/CD8+were higher in both groups at 3 days postoperatively, with higher indicator values in pilot group (P<0.05). The totalcomplication rate within 6 months of follow-up was lower in pilot group than in control group (4.35% vs 17.39%, P<0.05).Conclusion Low-temperature plasma surgery is effective and safe in children with OSAHS, and it is considered that it mightbe related to its contributions to improvements in surgery-related indexes, inflammatory response, immune function, pain andsleep quality.
Last Update: 2025-07-25