Preparation and properties of degradable and high-porosity sodium alginate/organic composite calcium salt porous scaffolds for tissue engineering(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2025年第11期
- Page:
- 1514-1522
- Research Field:
- 生物材料与力学
- Publishing date:
Info
- Title:
- Preparation and properties of degradable and high-porosity sodium alginate/organic composite calcium salt porous scaffolds for tissue engineering
- Author(s):
- SUN Weijing1; WU Yutong1; OU Mingjun2; GU Hanliu1; ZUO Xiaoling1; LIU Xiaoying1; YANG Yong1; WANG Li1
- 1. School of Health and Intelligent Engineering, Chengdu Medical College, Chengdu 610500, China 2. School of Clinical Medicine, Chengdu Medical College, Chengdu 610500, China
- Keywords:
- Keywords: bone tissue engineering sodium alginate calcium citrate double salt freeze-drying porous scaffold
- PACS:
- R318；TQ619.7
- DOI:
- DOI:10.3969/j.issn.1005-202X.2025.11.017
- Abstract:
- Abstract: A porous composite scaffold is prepared through freeze-drying method using sodium alginate as the matrix and calcium citrate double salt as the functional enhancer. To thoroughly investigate the structure and properties of the composite scaffold, advanced instruments including Fourier transform infrared spectrometer, X-ray diffractometer, scanning electron microscope, and thermogravimetric analyzer are utilized for comprehensive structural characterization. Meanwhile, key properties such as porosity, mechanical performance, swelling ratio, gel fraction, and in vitro degradation rate are systematically tested and analyzed. The results show that the composite of sodium alginate and calcium citrate double salt is a physical complex. The porosity of the scaffold mainly ranges from 200 to 600 μm, and as the addition of double salt increases, the pore size firstly increases and then slightly decreases, while the pore distribution become more uneven. In terms of mechanical properties, with the gradual increase of the content of double salt in the scaffold, the mechanical properties of the scaffold are significantly improved. However, its swelling ratio and gel fraction exhibit decreasing trends. Additionally, the degradation rate of the alginate scaffold is relatively fast, while the addition of calcium citrate double salt does not significantly improve the degradation rate. This study not only provides valuable insights into the preparation and property research of porous composite scaffold composed of sodium alginate/calcium citrate double salt, but also offers important reference for their potential applications in biomedicine.
Last Update: 2025-12-01