Abstract

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Title:: A novel X-ray phase contrast imaging approach for clinical application

Author(s):: SUN Chengcheng1; ZHOU Chenpeng2; 3; WANG Yan2; 3; ZHANG Kai2; 3; 1. Department of Otolaryngology Head and Neck Surgery, Beijing Electric Power Hospital, State Grid Corporation of China, Beijing 100073, China; 2. Beijing Synchrotron Radiation Facility, X-ray Optics and Technology Laboratory, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; 3. School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, China

Keywords:: X-ray imaging; phase contrast; information extraction; biomedical imaging

Abstract:: A new X-ray phase contrast imaging method utilizing scanning absorption grid technology is proposed based on the study of X-ray phase contrast imaging with pinhole imaging principle. The method can effectively capture absorption, refraction, and scattering information of weakly absorbing biological samples. Experimental results show that the proposed method offers several advantages over traditional X-ray grating phase contrast imaging, including a simple imaging device, minimal X-ray source requirements, and enhanced compatibility with laboratory X-ray source or synchrotron radiation white beam. Consequently, it provides a new research mean for advancing current X-ray phase contrast imaging technology in clinical imaging research of large human organs.