Abstract

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Title:: Assessment of outcome in hypothermia therapy for neonatal hypoxic-ischemic encephalopathy using amplitude-integrated electroencephalography

Author(s):: HUANG Jun; XU Xuetao; ZENG Liming; YANG Caiyun; Chaohu Hospital of Anhui Medical University, Hefei 238100, China

Keywords:: Keywords: neonatal hypoxic-ischemic encephalopathy hypothermia therapy amplitude-integrated electroencephalography neuron-specific enolase

Abstract:: Objective To evaluate the efficacy of hypothermia therapy in neonates with hypoxic-ischemic encephalopathy (HIE) through the analysis of amplitude-integrated electroencephalography. Methods A retrospective analysis was conducted on 59 neonates with moderate to severe HIE. They were divided into observation group (n=31, hypothermia therapy) and control group (n=28, conventional therapy) according to different treatment protocols. Chi-square test, independent sample t-test, and one-factor Mann-Whitney U test were used for intergroup difference analysis. Results Significant differences between two groups were observed in lower boundary amplitude after 24 h of treatment, sleep-awake cycle after 72 h of treatment, and total scores after 72 h of treatment (P<0.05). After 48 and 72 h of treatment, the neonates in hypothermia therapy group had obviously lower neuro-specific enolase level than those in control group (P<0.05). Conclusion Early application of hypothermia therapy can significantly improve cerebral function in neonates with HIE and lower the neuro-specific enolase level.