SPEEDO: a rapid and accurate Monte Carlo dose calculation program for carbon ion therapy(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2024年第10期
- Page:
- 1189-1198
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- SPEEDO: a rapid and accurate Monte Carlo dose calculation program for carbon ion therapy
- Author(s):
- WU Jin1; LI Shijun1; WANG Yuxin1; CHANG Yankui1; PEI Xi2; CHEN Zhi1; CHEN Weiqiang3; LI Qiang3; XU Xie George1; 4
- 1. School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026, China 2. Anhui Wisdom Technology Company Limited, Hefei 238000, China 3. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730099, China 4. Department of Radiotherapy, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230026, China
- Keywords:
- Keywords: carbon ion therapy Monte Carlo electromagnetic process nuclear interaction
- PACS:
- R318；R811.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2024.10.001
- Abstract:
- Abstract: Objective To develop a rapid and accurate Monte Carlo program (simplified code for dosimetry of carbon ions, SPEEDO) for carbon ion therapy. Methods For electromagnetic process, type II condensed history simulation scheme and continuous slowing down approximation were used to simulate energy straggling, range straggling, multiple scattering, and ionization processes. For nuclear interaction, 5 types of target nuclei were considered, including hydrogen, carbon, nitrogen, oxygen, and calcium. The produced secondary charged particles followed the same condensed history framework. The study simulated the transport of carbon ions in 4 materials (water, soft tissues, lung, and bone), and the calculated doses were validated against TOPAS (a Monte Carlo simulation software for radiotherapy physics), followed by a comparison with dose measurements in a water phantom from the HIMM-WW (a medical heavy-ion accelerator facility in Wuwei). Results SPEEDOs simulation results showed good consistency with TOPAS. For each material, in the voxel region where the physical dose was greater than 10% of the maximum dose point, the relative maximum dose error of both was less than 2%. At treatment energy of 400 MeV/u, SPEEDOs computation time was significantly less than that of TOPAS (13.8 min vs 105.0 min). SPEEDOs calculation results also showed good agreement with HIMM-WW measurements in terms of lateral dose distribution and integrated dose depth curve. Conclusion SPEEDO program can accurately and rapidly perform Monte Carlo dose calculations for carbon-ion therapy.
Last Update: 2024-10-29