Effects of nasal endoscopic low temperature plasma ablation and nasal dynamical system-assisted resection on peripheral blood inflammatory markers and their correlations with recurrence of sinonasal inverted papilloma(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2025年第2期
- Page:
- 245-249
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Effects of nasal endoscopic low temperature plasma ablation and nasal dynamical system-assisted resection on peripheral blood inflammatory markers and their correlations with recurrence of sinonasal inverted papilloma
- Author(s):
- LI Zhong; LI Junmei; LI Yu; WANG Zhongliang
- Department of Otolaryngology, Chengdu First Peoples Hospital, Chengdu 610095, China
- Keywords:
- Keywords: endoscopic low temperature plasma ablation nasal dynamical system-assisted resection sinonasal inverted papilloma recurrence influence factor inflammatory factor
- PACS:
- R765.2；739.62
- DOI:
- DOI:10.3969/j.issn.1005-202X.2025.02.016
- Abstract:
- Abstract: Objective To analyze the effects of nasal endoscopic low temperature plasma ablation combined with nasal dynamical system-assisted resection on inflammatory markers in peripheral blood of sinonasal inverted papilloma (SINP) and their correlations with recurrence. Methods A retrospective analysis was performed on 60 SINP patients admitted to Chengdu First Peoples Hospital from May 2021 to May 2023, all of whom were treated with endoscopic low temperature plasma ablation and nasal dynamical system-assisted resection and another 60 healthy persons who underwent physical examination in the same period were enrolled and set as control group. The changes of peripheral blood inflammatory markers before and at various time points after operation were compared between control group and SINP patients. General data of patients were collected by self-made scales. The recurrence was recorded, and its influence factors were analyzed for further exploring and the correlation between recurrence and levels of peripheral blood inflammatory factors. Results Statistically significant differences between control group and SINP group were found in serum tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-8 (IL-8), eosinophilic cationic protein (ECP) and eosinophilic granulocytes (EOS) before operation, 3 days and 1 month after operation (all P<0.001). Univariate analysis identified that TNF-α, CRP, IL-6, IL-8, mitotic counts, atypical hyperplasia and course of disease were associated with postoperative recurrence in SINP patients. Spearman correlation analysis showed that the postoperative recurrence in SINP patients showed no correlation with IL-6 level (P>0.05), but positively correlated with TNF-α, CRP and IL-8 levels (P<0.05). Conclusion Nasal endoscopic low temperature plasma ablation combined with nasal dynamical system-assisted resection is effective for SINP, with a low postoperative recurrence rate. Moreover, peripheral blood inflammatory markers are closely related to the occurrence and development of SINP, which may be involved in the recurrence, and there is a synergistic effect.
Last Update: 2025-01-22