DCE-MRI features of cognitive dysfunction in patients with first-episode stroke and their diagnostic value(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2024年第3期
- Page:
- 327-332
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- DCE-MRI features of cognitive dysfunction in patients with first-episode stroke and their diagnostic value
- Author(s):
- WANG Lu1; CHEN Zhuangjun1; QIU Longhai2; WANG Jinben1
- 1. Department of Radiology, Hainan Western Central Hospital, Danzhou 571700, China 2. Cardio-Catheter Room, Danzhou Peoples Hospital, Danzhou 571700, China
- Keywords:
- Keywords: first-episode stroke cognitive dysfunction dynamic contrast-enhanced magnetic resonance imaging diagnostic value risk degree
- PACS:
- R816.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2024.03.010
- Abstract:
- Abstract: Objective To investigate the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters for cognitive dysfunction in first-episode stroke, thereby providing reference for the early clinical assessment of the risk of cognitive dysfunction in stroke and formulation of intervention programs. Methods A total of 122 patients with first-episode stroke were enrolled and divided into occurrence group (n=53) and non-occurrence group (n=69) according to whether they had cognitive dysfunction. Additionally, 53 patients with non-cerebrovascular cognitive dysfunction were selected as control group. All patients underwent DCE-MRI examination after admission. The 3 groups and patients with different degrees of cognitive dysfunction were compared for DCE-MRI parameters, including interstitium-to-plasma rate constant (Kep), volume transfer constant (Ktrans), volume fraction of extravascular extracellular space (Ve), and volume fraction of plasma (Vp). The correlations of DCE-MRI parameters with the degree of cognitive dysfunction were analyzed, along with their diagnostic value for cognitive dysfunction and evaluation value for the risk of cognitive dysfunction after first-episode stroke. Results Both occurrence group and non-occurrence group had higher levels of Ktrans, Ve and Vp than control group, and these parameters were higher in occurrence group than non-occurrence group (P<0.05). Ktrans, Ve and Vp of patients with different degrees of cognitive dysfunction differed significantly (P<0.05), and they were increased significantly with the aggravation of cognitive dysfunction. Ktrans, Ve and Vp were all positively correlated with the degree of cognitive dysfunction (P<0.05). The AUC for the combined diagnosis using Ktrans, Ve and Vp was 0.921, significantly higher than single index (P<0.05). The risks of cognitive dysfunction in first-episode stroke patients with higher levels of Ktrans, Ve and Vp were 3.077, 1.944 and 2.313 times of the low-level, respectively. Conclusion DCE-MRI can be used to diagnose cognitive dysfunction in first-episode stroke, providing reference for early clinical prediction of cognitive dysfunction after stroke.
Last Update: 2024-03-27