Quantitative evaluation of rheumatoid synovitis with TIC analysis of DCE-MRI image(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2024年第4期
- Page:
- 426-432
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Quantitative evaluation of rheumatoid synovitis with TIC analysis of DCE-MRI image
- Author(s):
- MAO Jinling1; ZHU Zhongqi1; LI Yinghao1; HE Dongyi2; JIANG Ting2; XIA Tian1; SHI Jie2; WANG Hongzhi1
- 1. Shanghai Key Laboratory of Magnetic Resonance/School of Physics and Electronic Science, East China Normal University, Shanghai 200062, China 2. Department of Medical Imaging, Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 200523, China
- Keywords:
- Keywords: synovitis pannus wrist joint magnetic resonance imaging time-intensity curve analysis
- PACS:
- R312；O482.53
- DOI:
- DOI:10.3969/j.issn.1005-202X.2024.04.005
- Abstract:
- Abstract: Objective To improve the diagnostic sensitivity to rheumatoid arthritis (RA) by quantitatively evaluating and visualizing the shape and quantity of synovial pannus, especially inflammatory pannus, thereby providing reliable evidence for clinical medication guidance. Methods The wrists of 18 patients with RA confirmed by clinicopathology were examined with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and the region of interest was delineated for the 4th phase of the enhanced image. Spearman correlation analysis was used to evaluate the correlations of time-intensity curves (TIC) parameters, including early enhancement rate (MSI), enhancement amplitude difference (MSD), time to peak, tangent slope of fitted curve tail, and determine the independent feature which was then used to define the type of curves (type Ⅰ, slow enhancement type Ⅱ, fast enhancement followed by washout phase type Ⅲ, fast enhancement followed by plateau phase type Ⅳ, fast enhancement followed by slow enhancement increase). The volume of each type of TIC in ROI was calculated, and then compared with RAMRIS score for determining the TIC with the strongest correlation. Based on the characteristics of the selected curve, the quantitative classification of synovitis and two-dimensional multi-section color coding were carried out. Results MSI had significant positive correlation with MSD, and the volume of type Ⅱ TIC was correlated with RAMRIS score (r=0.812), indicating that in DCE-MRI image, the volume of type Ⅱ TIC was consistent with the type of synovitis pannus. Conclusion Statistical analysis of TIC is convenient for doctors to accurately and quantitatively analyze inflammatory pannus, providing important clinical information for diagnosis of disease severity and comparison before and after drug treatment in patients with RA.
Last Update: 2024-04-25