Effects of microgravity on osteoblast differentiation: a review(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2023年第6期
- Page:
- 750-754
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Effects of microgravity on osteoblast differentiation: a review
- Author(s):
- LIU Xiaolong1; CHEN Yi1; MA Ming1; JIA Gengxin1; GENG Bin2; XIA Yayi2
- 1. The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China 2. Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China
- Keywords:
- Keywords: microgravity osteoblast cell differentiation review
- PACS:
- R318
- DOI:
- DOI:10.3969/j.issn.1005-202X.2023.06.013
- Abstract:
- Abstract: In recent years, the molecular mechanism of microgravity regulating osteoblast differentiation has become a hot topic. Herein the effects of microgravity on osteoblast differentiation are reviewed, and the regulations of signaling pathways and epigenetic inheritance on osteoblast differentiation in a microgravity environment is summarized, with emphases on the action mechanisms of MAPK/ERK, Wnt/β-catenin, BMP/Smad signaling pathways and non-coding RNA. Finally, the current therapeutic measures for bone loss in a microgravity environment are introduced for providing a theoretical basis for the treatment of bone loss in space microgravity through the promotion of osteogenic differentiation in the later stage.
Last Update: 2023-06-28