Abstract

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Title:: Roles of ultrasound, MRI and chromosomal gene detection in the diagnosis of fetal brain abnormalities

Author(s):: ZHANG Guoliang; WANG Lishun; LI Weiwei; HUA Tianshu; WANG Qichen; ZHAO Yaoyao; Department of Radiology, Maternal and Child Care Center of Qinhuangdao, Qinhuangdao 066000, China

Keywords:: Keywords: fetal dysplasia ultrasound magnetic resonance imaging chromosomal gene detection combined diagnosis

Abstract:: Abstract: Objective To explore the clinical value of the combination of ultrasound (US), magnetic resonance imaging (MRI) and chromosomal gene detection in the diagnosis of fetal brain abnormalities. Methods A retrospective analysis was carried out on 120 pregnant women with imaging findings suggesting possible brain abnormalities in the fetuses. The diagnosis rates of MRI and US were analyzed by comparing fetal chromosome microarray analysis (CMA) with brain US and MRI. Results There was no significant difference between MRI and US in diagnosis rate (P>0.05). The combination of US, MRI and CMA had a specificity of 90.83%, sensitivity of 90.00%, false positive rate of 10.83% and false negative rate of 10.00% for the diagnosis of fetal brain abnormalities. Conclusion Both US and MRI can effectively diagnose fetal brain abnormalities, but MRI is superior over US in the detection of cavity of septum pellucidum. US, MRI and CMA should be combined for pregnant women with the corresponding indications.