Abstract

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Title:: Effects of different doses of intensity-modulated radiotherapy combined with concurrent chemotherapy on survival and toxicity in patients with locally advanced lung cancer

Author(s):: JIANG Chengchuan1; LI Moli2; LIU Sha1; ZHU Zhongshan1; LI Xiaobing1; 1. Department of Oncology, Hunan Brain Hospital (the Second Peoples Hospital of Hunan Province), Changsha 410007, China 2. Department of Respiratory and Critical Care Medicine, Chenzhou No.1?eoples Hospital, Chenzhou 423000, China

Keywords:: Keywords: locally advanced lung cancer intensity-modulated radiotherapy medication survival time toxic and side effect

Abstract:: Abstract: Objective To explore the effects of different doses of intensity-modulated radiotherapy (IMRT) combined with concurrent chemotherapy on survival and toxicity in patients with locally advanced lung cancer. Methods A total of 96 patients with locally advanced lung cancer were randomly divided into control group (n=48) and observation group (n=48). The control group was treated with IMRT (62 Gy) and concurrent PC chemotherapy, while the IMRT dose in observation group was 50 Gy. The general clinical data of patients were recorded. The survival curves were drawn using K-M analysis, and the survival rates were compared using Log Rank [χ2] test. The incidence of radiation-induced toxicity in 1 month after treatment was recorded. Results The remission rate in observation group was 75.00%, close to 79.17% in control group (P>0.05). The overall survival rate and progression-free survival rate in observation group were higher than those in control group (P<0.05), and the median survival time was significantly longer than that in control group (P<0.05). The incidences of radiation-induced toxicity such as bone marrow suppression and radiation pneumonitis in observation group were significantly lower than those in control group (P<0.05). Conclusion Reducing IMRT dose can relieve radiation-induced toxicity and prolong survival in patients. IMRT combined with concurrent chemotherapy can cause favorable clinical remission.