Abstract

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Title:: Online BNCT boron concentration monitoring method based on Monte Carlo simulation and human body model

Author(s):: HOU Zhenfeng1; GENG Changran1; 2; 3; TIAN Feng1; ZHAO Sheng 1; TANG Xiaobin1; 2; 3; 1. Department of Nuclear Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China 2. Key Laboratory of Nuclear Technology Application and Radiation Protection in Astronautics, Nanjing 211106, China 3. Joint International Research Laboratory on Advanced Particle Therapy, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China

Keywords:: Keywords: boron neutron capture therapy Monte Carlo generative adversarial network boron concentration monitoring

Abstract:: Abstract: The existing technology is difficult to realize real-time and online monitoring of boron concentration distribution. Therefore, a novel method for the online monitoring of boron concentration based on Compton camera for dual-energy prompt gamma imaging is proposed, and its feasibility is verified with Monte Carlo simulation. The proposed method uses generative adversarial network to quickly improve the quality of the reconstructed image of Compton camera. The trained network can optimize the original image within 0.83 s, and compared with the reconstructed image with back projection, the optimized image is closer to the real prompt gamma distribution image. The calculation of boron concentration distribution using the proposed method is realized on the constructed model of dual-energy prompt gamma detection based boron concentration monitoring system. The calculated average boron concentration is 86.91 ppm in the tumor area, and 18.37 ppm in the normal tissue area. The calculated average ratio of the boron concentration in the tumor area to that in the normal tissue area is 4.75, with a calculation error of 5.00%, which verifies the feasibility of the novel method for boron concentration monitoring based on dual-energy prompt gamma detection. The study provides new ideas and theoretical guidance for the online monitoring of boron concentration in boron neutron capture therapy.