Abstract

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Title:: Comparison among 3 dose schedules in stereotactic body radiotherapy for peripheral lung cancer based on radiobiological models

Author(s):: HUANG Baotian1; LIN Peixian2; LUO Limei1; WANG Ying1; 1. Department of Radiation Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515041, China 2. Department of Nosocomial Infection Management, the Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China

Keywords:: radiobiological model peripheral lung cancer stereotactic body radiotherapy dose schedule

Abstract:: Abstract: Objective To investigate the effects of 3 common dose schedules, namely 3×15 Gy, 4×12 Gy and 3×18 Gy, in stereotactic body radiotherapy for peripheral lung cancer on tumor control probability (TCP) and the probabilities of occurrence of radiation-induced pneumonitis (RIP), chest wall pain (CWP) and radiation-induced rib fracture (RIRF) using radiobiological models. Methods The CT images of 20 cases of peripheral lung cancer were collected. Three groups of treatment plans were designed based on 3 dose schedules. The TCP and the probabilities of occurrence of RIP, CWP and RIRF in each dose schedule were calculated by radiobiological models. Results Dose schedule had trivial effects on TCP. Radiation-induced toxicities in 3×18 Gy dose schedule was the highest, followed by 3×15 Gy dose schedule and 4×12 Gy dose schedule. Moreover, the probabilities of occurrence of RIP, CWP and RIRF in 3×18 Gy dose schedule were significantly higher than those in the other 2 dose schedules. Conclusion There is no significant difference in TCP among 3 different dose schedules. The radiation-induced toxicities in 4×12 Gy dose schedule is the lowest and 3×18 Gy dose schedule results in higher probabilities of occurrence of RIP, CWP and RIRF. The adjacence between the tumor and organs-at-risk should be considered before clinical treatment for determining patient-specific dosing strategy and implementing individualized treatment.