Abstract

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Title:: Feasibility of establishing a whole-body organ dose database for radiotherapy using automatic segmentation and fast Monte Carlo calculation

Author(s):: QIU Tao1; GAO Ning1; PI Yifei2; WANG Haiyang2; QI Yaping3; CHENG Bo1; PEI Xi1; 4; XU Xie1; 5; 1. School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230025，China 2. Department of Radiotherapy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 3. Institute of Ionizing Radiation Metrology, National Institute of Metrology, Beijing 100029, China 4. Anhui Wisedom Technology Co., Ltd, Hefei 230088, China 5. Department of Radiotherapy, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China

Keywords:: Keywords: esophageal cancer automatic segmentation Monte Carlo normal tissue complication probability

Abstract:: Abstract: Objective To discuss the feasibility of establishing a whole-body organ dose database platform for radiotherapy. Methods The automatic segmentation software DeepViewer?based on deep learning was used to delineate organs in whole-body CT of a patient with esophageal cancer, and the Monte Carlo software ARCHER accelerated by GPU was used to calculate the dose profile. Finally, the Lyman-Kutcher-Burman (LKB) model was used to calculate the normal tissue complication probability (NTCP). Results For this case, the whole-body organ dose database was established successfully using DeepViewer? ARCHER and LKB model. It was found that the closer to the target area, the greater the organ dose. The heart was closest to the target area, and it was irradiated with 14.11 Gy, but its NTCP calculated by LKB model was 0.00% due to its special model parameters. The left and right lungs were irradiated with 3.19 and 1.16 Gy, respectively, but their NTCP were larger (2.13% and 1.60%, respectively). Head and neck organs (optic chiasm, optic nerve and eyes) and abdominal organs (rectum, bladder and femoral head) which are far from target area were irradiated with about 9 and 2 mGy, respectively, and their NTCP were approximately 0.00%. Conclusion The establishment of whole-body organ dose database using automatic segmentation software DeepViewer? Monte Carlo software ARCHER and LKB model is practicable.