Abstract

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Title:: Factors affecting electric field stress on cardiomyocyte and electrical energy stored in cell membrane

Author(s):: ZHANG Hui; ZHANG Xiaodi; College of Physics and Electronic Engineering, Xianyang Normal University, Xianyang 712000, China

Keywords:: Keywords: cardiomyocyte electric field stress electric energy stored in cell membrane dielectric constant

Abstract:: Abstract: Objective To explore the factors affecting the electric field stress on myocardial cells and the electrical energy stored in the cell membrane. Methods By solving the boundary value problem, the potential distributions inside and outside the cells were obtained, and the factors affecting the energy stored in the cell membrane and the electric field stress distribution on cardiomyocyte were analyzed by the theory of bio-electromagnetics and the electric field stress tensor method. Results With larger cell radius, the polar angle corresponding to the junction point of the pulling force and pressure acting on the cell was larger, and the change rates of the electric field normal and tangential stresses with the dielectric constant of the extracellular medium were also larger. The stress caused by the electric field and the electric energy stored in the cell membrane changed obviously within a small cell radius otherwise, the stress and the change rate changed little with cell radius. Conclusion Both the radius of cardiomyocyte and the dielectric constant of extracellular medium affect the electric field stress and the electric energy stored in the cell membrane, and the cells with smaller radius are more easily affected by the additional direct-current electric field. Direct-current electric field can lead to cell deformation, fusion, rotation, and the changes of the ion trans-membrane migration, thereby resulting in cell biological effects.