Effects of radiation dose to pharyngeal constrictor muscle on swallowing function in patients receiving intensity-modulated radiotherapy for pharyngeal cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2021年第11期
- Page:
- 1338-1342
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Effects of radiation dose to pharyngeal constrictor muscle on swallowing function in patients receiving intensity-modulated radiotherapy for pharyngeal cancer
- Author(s):
- DOU Yanxian1; LIU Yuanying2; WANG Shuaibing3
- 1. Department of Cardiology, Langfang Peoples Hospital, Langfang 065000, China 2. Department of Geriatrics, Hebei Petro China Center Hospital, Langfang 065000, China 3. Department of Oncology, Hebei Petro China Center Hospital, Langfang 065000, China
- Keywords:
- Keywords: pharyngeal cancer intensity-modulated radiotherapy pharyngeal constrictor muscle swallowing function
- PACS:
- R811.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2021.11.004
- Abstract:
- Abstract: Objective To observe the relationship between radiation dose to pharyngeal constrictor muscle and swallowing function in patients receiving intensity-modulated radiotherapy (IMRT) for pharyngeal cancer. Methods A total of 80 patients with pharyngeal cancer were enrolled in the study, and all patients were treated by IMRT for 6 months. The radiation dose to pharyngeal constrictor muscle was determined according to the treatment needs of patients. The swallowing function scores of patients were recorded at the 1st month, 3rd months and 6th months after IMRT, and the correlation between radiation dose to pharyngeal constrictor muscle and swallowing function score was analyzed. After the swallowing function of patients was evaluated at the end of radiotherapy, the patients were divided into normal swallowing function, mild, moderate and severe dysphagia. The radiation dose to pharyngeal constrictor muscle was compared between mild or no dysphagia group and moderate-to-severe dysphagia group, and regression analysis was used to examine the effects of radiation dose to pharyngeal constrictor muscle on swallowing function. Results The each dimensional and total scores of MDADI reached the highest at the 1st month after radiotherapy, followed by the 3rd month and the 6th month after radiotherapy. The differences in MDADI scores at different time points were statistically significant (P<0.05). The radiation doses to superior, middle and inferior pharyngeal constrictor muscles in 80 patients with pharyngeal cancer were (44.72±5.58), (48.94±6.17) and (38.95±4.74) Gy, respectively, and the total radiation dose to pharyngeal constrictor muscle was (132.61±28.52) Gy. The results of general linear bivariate Pearson correlation analysis showed that the total score of MDADI at different time points was negatively correlated with the total radiation dose to pharyngeal constrictor muscle. At the end of radiotherapy, there were 29 cases with normal swallowing function, 18 cases with mild dysphagia, 21 cases with moderate dysphagia and 12 cases with severe dysphagia. After preliminary comparison of radiation dose to pharyngeal constrictor muscle between moderate-to-severe dysphagia group and mild or no dysphagia group, the result of multiple Logistic regression analysis revealed that high radiation dose to pharyngeal constrictor muscle was a risk factor for moderate-to-severe dysphagia occurring at the end of radiotherapy (OR>1, P<0.05). Conclusion The radiation dose to pharyngeal constrictor muscle can affect the swallowing function in patients receiving IMRT for pharyngeal cancer. With the increase of radiation dose, the swallowing function in patients is decreased, and the risk of dysphagia is increased.
Last Update: 2021-11-26