Abstract

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Title:: Brainnetome atlas-based investigation of white matter structural networks in drug-na?e first-episode major depressive disorder

Author(s):: WU Huawang1; 3; SHE Shenglin2; ZHENG Wei2; WU Fengchun2; 3; 1. Department of Imaging, the Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China 2. Department of Psychiatry, the Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China 3. Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou 510370, China

Keywords:: major depressive disorder diffusion tensor imaging brainnetome atlas brain network

Abstract:: Graph theory is adopted to analyze the diffusion tensor imaging data of drug-na?e first-episode major depressive disorder (MDD), aiming to explore the changes of white matter structural networks in MDD patients. Compared with those in healthy controls, the topological properties of brain networks in MDD patients are damaged, and the changes are mainly found in bilateral parahippocampal gyrus, bilateral basal ganglia, bilateral inferior parietal lobule, the left postcentral gyrus, the left paracentral lobule, the right middle temporal gyrus, the right superior parietal lobule, the right insular lobe, the right medio ventral occipital cortex, the right cingulate gyrus and the right thalamus. Moreover, a correlation analysis shows that the node betweenness of the right superior parietal lobule and the right insular lobe in MDD patients are positively correlated with the course of disease, and that the node betweenness of the right thalamus and the left parahippocampus as well as the nodal degrees of the left parahippocampus and the right inferior parietal lobule in MDD patients are positively correlated with the score of Hamilton rating scale for depression.