Abstract

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Title:: The therapeutic effect of intensity modulated radiotherapy on brain metastases from lung cancer with simultaneous boost of three different fractionated doses

Author(s):: LIU Jine1; SHEN Yongqi1; LIANG Xunsi2; YE Jianzhong3; LIN Deshuai1; HUANG Dingyi1; LIN Feng1; MENG Jingmin1; 1. Department of Oncology, Liutie Central Hospital Affiliated to Guangxi Medical University, Liuzhou 545007, China 2. Department of Thoracic Surgery, Longtan Hospital, Guangxi Zhuang Autonomous Region, Liuzhou 545005, China 3. Department of Oncology, Longtan Hospital, Guangxi Zhuang Autonomous Region, Liuzhou 545005, China

Keywords:: Keywords: fractionated dose synchronous boost intensity modulated radiotherapy brain metastases from lung cancer toxic and side effects survival rate

Abstract:: Objective To analyze the therapeutic effect of intensity modulated radiotherapy on brain metastases from lung cancer with synchronous boost treatments of three different fractionated doses. Methods 75 patients with lung cancer brain metastases was selected and randomly divided into three groups. Each group had 25 cases, and all received intensity modulated radiotherapy. Group A: 40 Gy/20f (2.0 Gy/f) for whole brain and 46 Gy/20f (2.3 Gy/f) of simultaneous boost for tumor area group B: 40 Gy/20f (2.0 Gy/f) for whole brain and 52 Gy/20f (2.6 Gy/f) of simultaneous boost for tumor area group C: 40 Gy/20f (2.0 Gy/f) for whole brain and 58 Gy/20f (2.9 Gy/f) of simultaneous boost for tumor area. Compare the therapeutic effects and toxic and side effects of the three groups. Results After one month of treatment, there was no statistical difference in the total effective rate of local control among the three groups (P>0.05). The median survival time of group C was significantly higher than that of group A and group B (P<0.05). Follow-up for one year showed that the survival rate of group C was higher than that of group A (P<0.05). There was no statistical difference in toxic and side effects among the three groups (P>0.05). Conclusion Intensity modulated radiotherapy with synchronous boosts of three different fractionated doses has significant effects on brain metastases from lung cancer, but comparatively, the therapeutic effect of large doses is more accurate.