Abstract

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Title:: Effects of mechanical properties and structure of optic nerve head on the deformation of lamina cribrosa

Author(s):: CAO Hongjian1; LIU Zhicheng1; 2; QIAN Xiuqing1; 2; 1. School of Biomedical Engineering, Capital Medical University, Beijing 100069, China 2.Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Beijing 100069, China

Keywords:: Keywords: glaucoma optic nerve head lamina cribrosa mechanical properties finite element analysis

Abstract:: Abstract: Objective To study the effects of mechanical properties and structure of optic nerve head (ONH) on the deformation of lamina cribrosa based on an axisymmetric model of eyeball including lamina cribrosa. Methods An axisymmetric finite element model of eyeball including lamina cribrosa was established based on the geometrical parameters of the ONH of glaucoma patients and normal controls, and with reference to the results of the literature. The effects of mechanical factors and geometrical parameters of ONH on the deformation of lamina cribrosa were analyzed. Results Increased intraocular pressure made lamina cribrosa move backward, and as intraocular pressure was increased, the degree of lamina cribrosa deformation was increased. The Youngs modulus of sclera, lamina cribrosa and dura mater had great effects on the deformation of lamina cribrosa. Moreover, thickness of lamina cribrosa, cup depth and cup width all affected the deformation of lamina cribrosa. Due to the specific structure and mechanical properties of glaucoma patients, the lamina cribrosa of glaucoma patients was more sensitive to intraocular pressure and intracranial pressure. Conclusion The finite element method can be used to study the factors affecting the deformation of lamina cribrosa, thereby providing some reference for the early diagnosis of glaucoma.