Effects of vascular tortuosities on pseudo-continuous arterial spin labeling and correction
effects of flow-driven adiabatic inversion(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2021年第9期
- Page:
- 1113-1118
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Effects of vascular tortuosities on pseudo-continuous arterial spin labeling and correction
effects of flow-driven adiabatic inversion
- Author(s):
- YUAN Weiwen1; 2; JIANG Guihua2; LUO Zebing1
- 1. the First School of Clinical Medical, Guangdong Medical University, Zhanjiang 524023, China 2. Department of Imaging,
Guangdong Second Provincial General Hospital, Guangzhou 510020, China
- Keywords:
- pseudo-continuous arterial spin label vascular tortuosity flow-driven adiabatic inversion
- PACS:
- R318；R445.2
- DOI:
- 10.3969/j.issn.1005-202X.2021.09.012
- Abstract:
- Objective To investigate the effects of vascular tortuosities on the pseudo-continuous artery spin labeling (PCASL) and
the correction effects of flow-driven adiabatic inversion used for labeling. Methods All subjects underwent 4 PCASL scans,
including 2 default and 2 modified protocols, and the subjects were divided into control group (the labeling plane intersected at
straight parts of vessels) and experimental group (the labeling plane intersected at vascular tortuosities) according to the geometric
relationships between the labeling plane and vascular tortuosities. The 2 modified protocols increased the labeling plane distance
to 95 and 100 mm, respectively, for avoiding vascular tortuosities. The differences in the PCASLmeasurement results in each group
were compared and statistically analyzed.Amathematical model of adiabatic inversion was also established to analyze the effects
of the technical principles of flow-driven adiabatic inversion on PCASL. Results The measurement results of the second default
and the first modified protocol of the two groups were not statistically different from those of the first default protocol (P>0.05).
However, the measurement results of the second modified protocol in both groups were statistically different from those of the
first default protocol (P<0.05), and experimental group had a more obvious downward trend than control group. Conclusion The
robustness, applicability and repeatability of PCASL are dependent on the blood displacement dependence and adiabaticity of flowdriven
adiabatic inversion. The effects caused by vascular tortuosities located inside the labeling plane and those passing through
the labeling plane multiple times can be corrected by flow-driven adiabatic inversion, thus there is no actual interference with the
PCASL measurement results. The vascular tortuosities between the labeling plane and the imaging area may lower the PCASL
measurement results due to T1 effect.
Last Update: 2021-09-27