Curative effects of high-dose and routine fractionated intensity-modulated radiotherapy
separately combined with 89SrCl2 intravenous injection on bone metastasis of lung cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第9期
- Page:
- 1111-1114
- Research Field:
- 医学人工智能
- Publishing date:
Info
- Title:
- Curative effects of high-dose and routine fractionated intensity-modulated radiotherapy
separately combined with 89SrCl2 intravenous injection on bone metastasis of lung cancer
- Author(s):
- GUO Lianhong1; ZHAO Suhua2; LI Bin3; YU Xueqing1; DUAN Lisha4
- 1. Department of Nuclear Medicine，the First Hospital of Zhangjiakou City, Zhangjiakou 075000, China 2. Department of Dialysis, the
First Hospital of Zhangjiakou City, Zhangjiakou 075000, China 3. Department of Orthopaedics, the First Hospital of Zhangjiakou City,
Zhangjiakou 075000, China 4. Department of Radiology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
- Keywords:
- high-dose intensity-modulated radiotherapy routine fractionated intensity-modulated radiotherapy 89SrCl2
intravenous injection lung cancer bone metastasis pain
- PACS:
- R816.8
- DOI:
- 10.3969/j.issn.1005-202X.2020.09.006
- Abstract:
- Objective To provide experimental data for clinical treatment of bone metastases by analyzing the curative effects
of high-dose and routine fractionated intensity-modulated radiotherapy (IMRT) separately combined with 89SrCl2 intravenous
injection on bone metastasis of lung cancer. Methods Eighty patients with bone metastases of lung cancer were divided into
high-dose IMRT group (group A, n=35) and routine fractionated IMRT group (group B, n=45). The short-term and long-term
curative effects, pain and occurrence of adverse reactions were compared between two groups. Results (1) There was no
significant difference in short-term curative effect between two groups (P>0.05). The tumor control probability in group A
was slightly higher than that in group B，without statistical differences (91.43% vs 84.44%, P>0.05). (2) The cumulative
survival rate of group A was 84.00%, higher than 66.50% of group B, without statistical differences (P>0.05). (3) After
treatment, the NRS scores in both groups were decreased. However, the NRS score of group A was lower than that of group
B, and the starting time of pain relief was shorter than that of group B (P<0.05). (4)There was no significant difference
between two groups in the incidence of grade III-IV adverse reactions such as leukopenia, thrombocytopenia, gastrointestinal
side effects, neurotoxicity and radiation-induced skin injuries (P>0.05). Conclusion The short-term and long-term curative
effects of high-dose and routine fractionated IMRT separately combined with 89SrCl2 intravenous injection are comparable on
bone metastasis of lung cancer. However, the pain relief of the former is more significant and faster. Moreover, compared
with routine fractionated IMRT, high-dose IMRT does not increase the incidence of grade III-IV adverse reactions.
Last Update: 2020-09-25