MRI signs in differentiation of IDH-1 mutant type and wild type of lower-grade gliomas(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第11期
- Page:
- 1384-1388
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- MRI signs in differentiation of IDH-1 mutant type and wild type of lower-grade gliomas
- Author(s):
- XUE Caiqiang1; 2; 3; KE Xiaoai1; 2; 3; DENG Juan1; 2; 3; LI Shenglin1; 2; 3; LIU Xianwang1; 2; 3; ZHOU Junlin1; 2; 3
- 1. Department of Radiotherapy, Second Hospital affiliated to Lanzhou University, Lanzhou 730030, China 2. Second Clinical School, Lanzhou Universty, Lanzhou 730030, China 3. Gansu Provincial Key Laboratory of Medical Imaging, Lanzhou 730030, China
- Keywords:
- Keywords: brain tumor lower-grade gliomas isocitrate dehydrogenase-1 magnetic resonance imaging
- PACS:
- R814.4
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.11.008
- Abstract:
- Abstract: Objective To compare and analyze the MRI signs of isocitrate dehydrogenase-1 mutant and wild-type of lower-grade gliomas (WHO Ⅱ-Ⅲ). Methods The clinical and MRI signs and molecular pathological data of 69 patients with lower-grade glioma confirmed by surgery and pathology were retrospectively analyzed. All cases were performed scans of T1WI, T2WI, FLAIR and T1WI enhanced sequence. The signs and indicators such as gender, age, location, number of lesions, tumor diameter, cystic necrosis, tumor border, hemorrhage, peritumoral edema, crossing of the midline, and degree of enhancement were statistically analyzed. Results The differences of tumor location between IDH-1 mutant and wild type in lower-grade gliomas was statistically significant (P<0.05). IDH-1 mutant was more commonly occurred in the frontal lobe than wild type. The enhancement degree of IDH-1 mutant consists of 83% of mild enhancement, 14% of moderate enhancement and 3% of severe enhancement, and the enhancement degree of wild type consists of 41%, 44%, and 15% respectively. Their differences were statistically significant (P<0.05). The maximum diameter of IDH-1 mutant necrosis was larger than that of wild type, and the difference was statistically significant (P<0.05). There were no statistically significant differences in the age of onset, gender, number of lesions, tumor boundaries, crossing of the midline, presence or absence of bleeding, maximum diameter of edema, maximum diameter of cystic change, and maximum diameter of necrosis (P>0.05). Conclusion The location, degree of enhancement, and maximum diameter of necrosis of lower-grade gliomas are of great value in evaluating the mutation status of IDH-1 before surgery.
Last Update: 2020-12-02