Capture and culture in situ of circulating tumor cells based on gelatin film substrate(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2021年第12期
- Page:
- 1549-1553
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Capture and culture in situ of circulating tumor cells based on gelatin film substrate
- Author(s):
- ZHANG Ke; ZHANG Taoye; HUANG Huiming
- School of Physics and Technology, Wuhan University, Wuhan 430072, China
- Keywords:
- circulating tumor cells gelatin film substrate culture in situ
- PACS:
- R-33
- DOI:
- DOI:10.3969/j.issn.1005-202X.2021.12.017
- Abstract:
- At present, there are some challenges in obtaining circulating tumor cells (CTCs) with high viability from blood. Herein a gelatin film substrate is designed for realizing the capture and culture in situ of CTCs. The maximum capture efficiency of the proposed substrate for CTCs reaches 86.8%. Because of the good biocompatibility of gelatin, CTCs can be directly cultured in situ after being captured by gelatin film substrate, which reduces the damages to the cells during the release process and is more beneficial for subsequent cellular analysis. The gelatin film substrate is expected to play a role in the clinical detection of CTCs.
Last Update: 2021-12-24