Abstract

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Title:: Advances in research on imaging evaluations of rat glioma and its microenvironment

Author(s):: DENG Juan1; 2; 3; LI Shenglin1; 2; 3; LIU Xianwang1; 2; 3; XUE Caiqiang1; 2; 3; ZHOU Junlin1; 3; 1. Department of Radiology, Lanzhou University Second Hospital, Lanzhou 730030, China 2. the Second School of Clinical Medicine, Lanzhou University, Lanzhou 730030, China 3. Key Laboratory of Medical Imaging of Gansu Province, Lanzhou 730030, China

Keywords:: Keywords: glioma tomography magnetic resonance imaging positron emission tomography review

Abstract:: Abstract: The establishment of animal model of glioma plays an indispensable role in understanding the occurrence, development and regression of glioma. As a non-invasive method, imaging can be used to not only realize macroscopic tumor imaging, but also qualitatively and quantitatively assess tumor microstructures and microscopic environmental changes. Herein the research status of imaging in evaluating glioma angiogenesis and anti-angiogenesis in rats, tumor hypoxia, tumor microstructure and their changes after treatment is reviewed and the relationships between the parameters of different imaging modalities and tumor histopathology are analyzed and finally the advantages of different imaging modalities are summarized. The review provides principle support for the application of imaging in the diagnosis and treatment of glioma, and new ideas for clinical diagnosis and treatment of glioma.