Measurement of natural frequency in rat brain(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第12期
- Page:
- 1560-1565
- Research Field:
- 医学生物物理
- Publishing date:
Info
- Title:
- Measurement of natural frequency in rat brain
- Author(s):
- LU Xingang; YIN Lu; AN Yun; WU Dandan; YANG Yikun; YANG Bintang; YAN Juntao
- 1.Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China2. State Key Laboratory of Mechanical System and Vibration, Shanghai Jiaotong University, Shanghai 200240, China
- Keywords:
- rat brain natural frequency nerve injury
- PACS:
- R318；R-33
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.12.017
- Abstract:
- Objective To identify the natural frequencies of rat brain tissue before and after common central nerve injury and peripheral nerve injury with an aim of providing the basis for the frequency selection of non-invasive brain stimulation techniques such as transcranial magnetic stimulation and transcranial acoustic wave stimulation as well as for the development of relevant animal experiments. Methods 24 SD rats were randomly divided into normal group, sciatic nerve injury (SNI) model group and cerebral ischemia reperfusion (MCAO) model group, with 8 rats in each group. SNI model group underwent sciatic nerve clamp injury MCAO model group underwent cerebral ischemia-reperfusion injury 7 days after the two model groups were modeled, the skulls and dura maters of three groups rats were gradually opened, and the rats brain units were carefully exposed. Frequency source output frequency, laser sensing real-time spectrum observation and time-frequency analysis method were used to obtain characteristic curve and identify the natural frequency that appears when the rat brain tissue amplitude B is maximum. Results The peaks of the natural frequency at the maximum amplitude of the brain tissue of each group of rats were relatively close. The normal group was (27.04±2.12) Hz, the SNI model group was (27.57±2.19) Hz, and the MCAO model group was (26.44±2.27) Hz. The natural frequency difference between the SNI model group and the normal group is not statistically significant (P>0.05), the difference between the MCAO model group and the normal group is not statistically significant (P>0.05), and the MCAO model group and the SNI model group also have no statistically significant difference. (P>0.05). Conclusion The natural frequency of brain tissue is relatively stable. There will be no big difference in the natural frequency of brain tissue even when stimulation of peripheral injury SNI and central damage MCAO was happened.
Last Update: 2020-12-30