Changes in salivary gland function before and after intensity-modulated radiotherapy for nasopharyngeal carcinoma and the relationship with irradiation doses(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第6期
- Page:
- 685-690
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Changes in salivary gland function before and after intensity-modulated radiotherapy for nasopharyngeal carcinoma and the relationship with irradiation doses
- Author(s):
- ZHENG Xiaoming1; KANG Min2; HU Kai2; WANG Rensheng2; WEI Zhixiao3; LI Junhong3; ZHANG Lan3
- 1. Department of Radiotherapy, No.923 Hospital of Chinese Peoples Liberation Army, Nanning 530021, China 2. Department of Radiotherapy, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China 3. Department of Nuclear Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
- Keywords:
- Keywords: nasopharyngeal carcinoma intensity-modulated radiotherapy salivary gland radionuclide imaging irradiation dose
- PACS:
- R818；R739.6
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.06.006
- Abstract:
- Abstract: Objective To investigate the changes of salivary gland function in patients with nasopharyngeal carcinoma (NPC) before and after intensity-modulated radiotherapy (IMRT) and discuss the relationship between the changes and irradiation doses. Methods Thirty NPC patients who underwent IMRT in the First Affiliated Hospital of Guangxi Medical University were examined with 99mTcO4-SPECT salivary gland dynamic imaging before and at 3 months after radiotherapy to determine the time-activity curve (TAC), maximum accumulation ratio (MAR) and acid-stimulated maximum secretion rate (MSR) of the parotid glands and the submandibular glands for studying the relationship between changes in salivary gland function and irradiation dose. Results The symptom of grade 1-2 dry mouth occurred at 3 months after radiotherapy. TAC showed that there were mainly mild to moderately damages to the parotid glands and the submandibular glands. The degree of dry mouth and TAC were positively correlated with the irradiation doses to the salivary glands. The MAR and MSR of the parotid gland and the MSR of the submandibular gland were significantly lower at 3 months after radiotherapy than those before radiotherapy (P<0.05), but the MAR of the submandibular gland was not reduced (P>0.05). There was no statistically significant difference in the MAR and MSR between affected salivary gland and contralateral salivary gland (P>0.05). The irradiation doses to the bilateral salivary glands were reasonable. Conclusion There are mild to moderate damages to the uptake and excretion functions of the salivary glands in NPC patients, which can cause grade 1-2 dry mouth. In IMRT for NPC, the doses to the salivary glands can be controlled in a reasonable range.
Last Update: 2020-07-03