Effects of different registration algorithms on cumulative dose of adaptive radiotherapy for advanced esophageal cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第9期
- Page:
- 1088-1094
- Research Field:
- 医学人工智能
- Publishing date:
Info
- Title:
- Effects of different registration algorithms on cumulative dose of adaptive radiotherapy for advanced esophageal cancer
- Author(s):
- ZHANG Jiarong1; 2; YANG Xin1; WANG Bin1; ZHENG Wanjia1; 3; HUANG Sijuan1
- 1. Sun Yat-sen University Cancer Center/State Key Laboratory of Oncology in South China/Collaborative Innovation Center for Cancer
Medicine/Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, China 2. Xinhua
College of Sun Yat-sen University, Guangzhou 510000, China 3. Air Force Hospital of Southern Theater of the Chinese Peoples
Liberation Army, Guangzhou 510507, China
- Keywords:
- advanced esophageal cancer image registration adaptive radiation therapy cumulative dose
- PACS:
- R735.1；R811.1
- DOI:
- 10.3969/j.issn.1005-202X.2020.09.002
- Abstract:
- Objective To study the effects of different registration algorithms on the cumulative dose of adaptive radiation
therapy for advanced esophageal cancer and to provide guidance for clinical application. Methods Eleven patients with
inoperable advanced esophageal cancer were selected and their two-course radiotherapy plans were imported in Velocity
sofware, with CTA image obtained in the second course of treatment as primary image and CTB obtained in the first course of
treatment as secondary image. Four registration algorithms, namely Rigid (Rd), Deformable Multi Pass (DMP), Rigid+
Deformable Multi Pass (Rd+DMP), Rigid+Extended Deformable Multi Pass (Rd+EDMP), were chosen for image
registration and dose accumulation. The registration accuracies of different registration algorithms were evaluated by the
Dice similarity index (DSC) of organs-at-risk (OAR), and the differences in the cumulative dose of target areas and OAR under the registrations by different algorithms were analyzed by paired-t test and rank sum test. Results The DSC of liver,
spinal cord and spinal cord with an expansion of 3 mm (spinal cord03) under the registration by DMP and Rd+DMP were
higher than those obtained by Rd+EDMP and Rd (P<0.05), and the heart DSC obtained by Rd was slightly higher than that
obtained by Rd+EDMP (P=0.02). The cumulative dose of target areas under the registrations by different algorithms showed
that the D50% and Dmean of PGTV under the registrations by Rd+DMP and Rd+EDMP were slightly lower than those under the
registration by Rd (P=0.035, P=0.044). The V100% of PGTV obtained by Rd+DMP was slightly higher than that obtained by
DMP (P=0.026) and was 0.653% higher than that obtained by Rd+EDMP (P=0.008). The D98% and V105% of PGTV-nd
obtained by Rd+DMP were slightly higher than those obtained by DMP (P=0.046, P=0.023), and the PGTV-nd V100% under
the registration by Rd were 2.118% and 2.137% higher than that under the registration by DMP and Rd+DMP, respectively (P
=0.028, P=0.037). There was no significant difference in the cumulative dose of PTV1 among all registrations (P>0.05). The
cumulative doses of OAR under the 4 different registration algorithms were relatively consistent. The V10 Gy,V20 Gy, V30 Gy, V40 Gy,
Dmean of the lungs and the V20 Gy，V30 Gy, V40 Gy and Dmean of the heart under the registration by DMP were lower than those under
the registration by Rd (P<0.05). Similarly, the Dmean of the heart and spinal cord obtained by DMP was lower than that
obtained by Rd+DMP and Rd+EDMP (P<0.05). Moreover, there was no statistical difference in the cumulative doses of liver
and spinal cord03. Conclusion DMP and Rd+DMP have a relatively high registration accuracy, and the consistence of OAR
cumulative dose under the registration by DMP was the lowest. Therefore, DMP can be used for the evaluation of cumulative
dose of adaptive radiotherapy for advanced esophageal cancer.
Last Update: 2020-09-25