Effect of electret combined with 5-fluorouracil on TGF-β/MMPs pathway during scar formation(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第9期
- Page:
- 1193-1197
- Research Field:
- 医学人工智能
- Publishing date:
Info
- Title:
- Effect of electret combined with 5-fluorouracil on TGF-β/MMPs pathway during scar formation
- Author(s):
- GUO Xin1; TU Ye2; YUAN Wang3; LIANG Yuanyuan1; JIANG Jian1; CUI Lili4
- 1. Department of Physics and Mathematics, Faculty of Health Service, the Second Military Medical University, Shanghai 200433, China
2. Shanghai East Hospital, Shanghai 200120, China 3. General Hospital of Northern Theater, Shenyang 110000, China 4. Department of
Inorganic Chemistry, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China
- Keywords:
- hypertrophic scar 5-fluorouracil electret TGF-βMMPs
- PACS:
- R318；R34
- DOI:
- 10.3969/j.issn.1005-202X.2020.09.021
- Abstract:
- Objective To investigate the inhibiting effect of electret combined with 5-fluorouracil (5-Fu) on scar formation and
discuss the related mechanisms. Methods Different patches, including electret, 5-Fu, and electret combined with 5-Fu, were
separately applied to the wound in mice, participating in the formation of hypertrophic scar. The scar hyperplasia index and
microstructure of wound tissues and the expressions of TGF-β,MMP1, TIMP1 andMMP2 in tissues were detected for studying
the inhibiting effect of electret combined with 5-Fu on scar formation and discussing the related mechanisms . Results (1) The
formation and growth of scar were effectively inhibited by electret, 5-Fu, and electret combined with 5-Fu, separately. After 4
weeks of treatments by different patches, the scar hyperplasia index was decreased to 85.8%, 85.1% and 64.9% of that in
control group, respectively (P<0.05). (2) All the treatments (electret, 5-Fu, and electret combined with 5-Fu) had effects on
TGF-β/MMPs pathway during scar formation. In treatment groups, TGF-β expression was inhibited and MMP1 expression
was up-regulated and MMP1/TIMP1 ratio was increased whereas MMP2 was down-regulated. The effect of electret
combined 5-Fu group was better than that of 5-Fu, followed by electret. Conclusion Like 5-Fu, electret can inhibit the growth
of scar, and they have a synergistic effect. The mechanism may be related to the expressions of TGF-β, MMP1, TIMP1 and
MMP2. The electret combined with 5-Fu is expected to improve the bioavailability of 5-Fu (reduce 5-Fu dose and decrease its
toxic effects) on the basis of achieving the same therapeutic effect.
Last Update: 2020-09-25