Dosimetric analysis of 4 types of simultaneous integrated boost radiotherapy for high-grade glioma(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2019年第12期
- Page:
- 1396-1399
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Dosimetric analysis of 4 types of simultaneous integrated boost radiotherapy for high-grade glioma
- Author(s):
- GUO Feibao
- Department of Radiotherapy, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
- Keywords:
- glioma; volumetric modulated arc therapy; intensity-modulated radiotherapy; radiotherapy dose; simultaneous integrated boost
- PACS:
- R815；R739.41
- DOI:
- DOI:10.3969/j.issn.1005-202X.2019.12.006
- Abstract:
- Abstract: Objective To investigate the dosimetric characteristics of the two- and three-stage simultaneous integrated boost methods for high-grade glioma using volumetric modulated arc therapy (VMAT) and static intensity-modulated radiotherapy (IMRT). Methods Four postoperative radiotherapy plans were designed for 21 randomly selected glioma patients, and the plans included the two- and three-stage simultaneous integrated boost VMAT (VMAT2 and VMAT3) as well as the two- and three-stage simultaneous integrated boost static IMRT (IMRT2 and IMRT3). Dose-volume histogram and cross-sectional isodose curve were used to evaluate the doses to target areas and normal tissues; and paired t-test was used to compare dosimetric differences among 4 plans. Results The CI of VMAT was better than that of IMRT. There was no significant difference between IMRT2 and IMRT3 in the dosimetric parameters of all brain except for V10; and the differences in the dosimetric parameters of all brain between VMAT2 and VMAT3 were trivial, without statistical significance. No statistical difference was found in the most of the dosimetric parameters of normal brain tissues near the tumor except for V10 and the V20, V30 and Dmean of some planning target rings. Moreover, the machine units were similar in VMAT and IMRT, without statistical differences. Conclusion As a postoperative radiotherapy for glioma, VMAT achieved a higher conformity index than IMRT. Compared with the two-stage simultaneous integrated boost radiotherapy, the three-stage simultaneous integrated boost radiotherapy for glioma can significantly increase the prescription dose to target areas while without increasing doses to organs-at-risk and brain tissues, having important application value in the treatment of glioma.
Last Update: 2019-12-24