Protection of cardiac function in tomotherapy for middle and lower thoracic esophageal carcinoma(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2021年第11期
- Page:
- 1355-1358
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Protection of cardiac function in tomotherapy for middle and lower thoracic esophageal carcinoma
- Author(s):
- FAN Chunbo; WANG Jing; HE Yanan; XI Daojun; LI Jianfeng; SUN Mao; LI Cong; GUO Qishuai; JIN Fu
- Radiotherapy Center, Chongqing University Cancer Hospital/Chongqing Cancer Institute/Chongqing Cancer Hospital, Chongqing 400030, China
- Keywords:
- Keywords: tomotherapy thoracic esophageal carcinoma intensity-modulated radiotherapy dosimetric comparison myocardial enzymogram
- PACS:
- R811.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2021.11.007
- Abstract:
- Abstract: Objective To compare the dose distribuction in the heart between tomotherapy (TOMO) and intensity-modulated radiotherapy (IMRT) for middle and lower thoracic esophageal carcinoma, and to analyze the myocardial enzymogram before and after TOMO, thereby evaluating the protective effect of TOMO for esophagus carcinoma on cardiac function. Methods A total of 37 patients with middle and lower thoracic esophageal squamous cell carcinoma were enrolled in the study. Both IMRT and TOMO plans were designed for each patient, and the dosimetric parameters of planning target volume (PTV) and the heart were compared between two radiotherapy strategies. Meanwhile, myocardial enzymes spectroscopy was performed one week before and after TOMO for comparing the changes in myocardial enzymogram. Results The maximum doses to PTV and the heart in TOMO were significantly lower than those in IMRT (P<0.05), and the V20, V30, V40, V50, V60 of the heart was significantly smaller in TOMO (P<0.05). There was significant difference between two radiotherapy strategies in the conformity indexs of PTV (P<0.05), but not in the the homogeneity index of PTV. Moreover, no significant difference was found in myocardial enzymogram before and after TOMO (P>0.05). Conclusion Under the condition that TOMO has a better dose distribution in the target area than IMRT, TOMO can significantly reduce the maximum dose to the heart, and the induced early myocardial injury is not obvious. Therefore, TOMO plays a better protection for the heart.
Last Update: 2021-11-27