Application of low radiation dose and low contrast agent scanning protocol combined with iterative reconstruction CT angiography in the diagnosis of congenital heart diseases in infants(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第2期
- Page:
- 185-189
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Application of low radiation dose and low contrast agent scanning protocol combined with iterative reconstruction CT angiography in the diagnosis of congenital heart diseases in infants
- Author(s):
- FAN Min; ZOU Meng; CHEN Tingyu; LI Juan; CHENG Wei
- Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China
- Keywords:
- Keywords: infant; congenital heart disease; computed tomography; X-ray computer; contrast agent; iterative reconstruction
- PACS:
- R814.42；R725.4
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.02.010
- Abstract:
- Abstract: Objective To explore the diagnostic value of Somatom Definition Flash of low radiation dose and low contrast agent combined with iterative reconstruction CT angiography in congenital heart diseases (CHD) in infants. Methods Eighty-six patients with suspected CHD for angiography were randomly divided into experimental group (44 cases) and control group (42 cases) for low radiation dose and low contrast agent scanning protocol and conventional scanning protocol, separately. The contrast agent, volumetric CT dose index (CTDIvol) and dose-length product in two groups were recorded, and the effective radiation dose was calculated. The image quality was independently diagnosed by 2 experienced radiologists and assessed by 4 scores, and Kappa test was used for the consistency evaluation. The signal-to-noise ratios and contrast-to-noise ratios in two groups were measured. The diagnostic values of the two scanning protocols were compared with the surgical results or digital subtraction angiography as the gold standard. Results The effective radiation doses of infants in experimental group and control group were (0.30±0.16) mSv and (0.97±0.34) mSv, respectively, with statistical differences (P<0.01), and the injection of contrast agents were (10.01±1.87) mL and (16.04±3.17) mL, respectively, with statistical differences (P<0.05). Although the image quality score of experimental group was higher than that of control group, with statistical differences (3.40±0.57 vs 2.9±0.89, P<0.05), both the image quality of the two groups met the diagnostic requirements. There were significant differences in contrast-to-noise ratio between two groups. The diagnostic sensitivities of experimental group and control group were 97.4% and 97.9%; the specificities were 98.7% and 97.7%; and the diagnostic accuracies were 98.3% and 97.8%, respectively. Conclusion The low radiation dose and low contrast agent scanning protocol combined with iterative reconstruction technique which can greatly reduce CT radiation dose and contrast agent injection for infant patients, obtain image quality which is better than that obtained by conventional scanning protocol and achieve a higher diagnostic accuracy is suitable for clinical application.
Last Update: 2020-03-03