Feasibility of using photo-nuclear reaction of nanoparticles to achieve in situ activation therapy(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2020年第6期
- Page:
- 696-701
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Feasibility of using photo-nuclear reaction of nanoparticles to achieve in situ activation therapy
- Author(s):
- ZHANG Guoliang; HU Yimin
- School of Physics and Technology, Wuhan University, Wuhan 430072, China
- Keywords:
- Keywords: photo-nuclear reaction gold nanoparticle Geant4 cell model physical model
- PACS:
- R318；O572.2
- DOI:
- DOI:10.3969/j.issn.1005-202X.2020.06.008
- Abstract:
- Abstract: Objective To simulate the nanoparticles inside the cells that are irradiated by 13.5 MeV and 6 MeV X-rays by Monte Carlo toolkit Geant4, and to explore the dose contributions coming from the nanopaticles activated by photo-nuclear reaction. Methods Taking gold nanoparticles (GNP) as the example, the situations that the GNP inside the cells were irradiated by 13.5 MeV and 6 MeV X-rays were simulated, and the dose depositions caused by GNP were studied. A water tank (0.426 mm×0.426 mm×0.426 mm) that contained 1 103 cells was taken as the container of GNP. Based on the irradiation by 6 MeV and 13.5 MeV X-rays, the dose depositions in two kinds of cell models (with and without GNP) were analyzed. Results The dose contribution of GNP irradiated by 13.5 MeV X-rays reached 5.12 cGy which was 20.19% of the total dose deposition (25.37 cGy), while the dose contribution of GNP irradiated by 6 MeV X-rays reached 2.87 cGy which was 12.46% of the total dose deposition (23.05 cGy). Compared with the dose contribution under the irradiation by 6 MeV X-rays, the dose contribution coming from GNP activated by photo-nuclear reaction under the irradiation by 13.5 MeV X-rays accounted for about 7.7%. Conclusion The study on the GNP in cell models shows that GNP does lead to additional dose depositions. Because of the low dose contribution caused by photo-nuclear reaction, it is impossible to take the GNP activated by photo-nuclear reaction as in situ activated radiation source.
Last Update: 2020-07-03