Preliminary study on intracranial iron metabolism in patients with multiple sclerosis using MR quantitative susceptibility mapping(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2019年第6期
- Page:
- 672-676
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Preliminary study on intracranial iron metabolism in patients with multiple sclerosis using MR quantitative susceptibility mapping
- Author(s):
- LONG Liu; GUO Zhuoxin; ZHANG Li’na; KANG Zhuang; CHEN Shaoqiong
- Department of Radiology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510000, China
- Keywords:
- ; Keywords: quantitative susceptibility mapping; multiple sclerosis; intracranial iron content; normal-appearing white matter
- PACS:
- R445.2；R35
- DOI:
- DOI:10.3969/j.issn.1005-202X.2019.06.010
- Abstract:
- Abstract: Objective To apply quantitative susceptibility mapping (QSM) for observing the characteristics of the lesions and the changes in the magnetic susceptibility of normal-appearing white matter (NAWM) and gray matter nuclei in patients with multiple sclerosis (MS). Methods The QSM data of 23 MS patients and 9 normal controls were collected. The differences in the magnetic susceptibility of NAWM and gray matter nuclei between MS patients and normal controls were analyzed with independent-samplest test. The correlations among gray matter nuclei, mean magnetic susceptibility of lesions, total lesion load and clinical indicators of MS patients were investigated by Spearman correlation analysis. Results Three types of MS plaques were observed, including nodular hyperintense, annular hyperintense and isointense. Statistical differences were found in the mean magnetic susceptibility of NAWM between MS patients and normal controls (P<0.05), but not in the mean magnetic susceptibility of gray matter nuclei. The mean magnetic susceptibility of lesions was positively correlated with the magnetic susceptibility of putamen and dentate nuclei (P<0.05). The total lesion load had a positive correlation with the magnetic susceptibility of pallidus, thalamus and red nuclei (P<0.05). The expanded disability status scale score had no correlation with mean magnetic susceptibility of lesions and the magnetic susceptibility of gray matter nuclei. Conclusion QSM can be used for the quantitative detection of intracranial iron content in MS patients, providing a wider time window for determining the activity of non-enhanced lesions. MS patients have potential pathophysiological abnormalities in intracranial NAWM.
Last Update: 2019-06-25