Abstract

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Title:: Comparison of dose calculation by two Monte Carlo formulas under different uncertainties in treatment of lung cancer

Author(s):: CAO Yangsen1; XIE Hongliang1; ZHANG Kejia2; YU Chunshan1; SUN Yongjian1; LIU Yongming1; ZHANG Huojun1; 1. Department of Radiation Oncology, Changhai Hospital, Naval Medical University, Shanghai 200433, China; 2. Department of Clinical Medicine, Medical School of Nantong University, Nantong 226001, China

Keywords:: Keywords: lung cancer; Monte Carlo algorithm; uncertainty; dose distribution

Abstract:: Abstract: Objective To compare the variations in dose calculation by per calculation (PC) formula and per control point (PCP) formula of Monaco treatment planning system under different uncertainties in the treatment of lung cancer. Methods Target areas and organs-at-risk (OAR) were contoured in Monaco treatment planning system after CT-simulation based localization for 19 patients with lung cancer. Final dose calculation was carried out by PC formula and PCP formula under the uncertainty of 3%, 1%, 0.3% and 0.1%. The dosimetric indexes of target areas and OAR were compared, including the D95, D99, D5, D1, Dmin, Dmax of PGTV and PCTV, the Dmean, Dmax, V5, V10, V20 and V30 of the whole lung, and the Dmax of spinal cord. Results The order of the uncertainty of calculation results by Monte Carlo formulas in Monaco treatment planning system was as followed: PCP_0.1%