Abstract

Info

Title:: Application of extended-field intensity-modulated radiotherapy for locally advanced cervical cancer

Author(s):: HE Lin; Tumor Area, Yulin Second People’s Hospital, Yulin 537000, China

Keywords:: ; Keywords: extended-field intensity-modulated radiotherapy; locally advanced cervical cancer; progression-free survival; survival rate

Abstract:: Abstract: Objective To study the effects of extracorporeal extended-field intensity-modulated radiotherapy for locally advanced cervical cancer. Methods A total of 120 patients with locally advanced cervical cancer of stage IIB-IVA were randomly divided into control group and observation group, with 60 cases in each group. Conventional synchronous radiochemotherapy was adopted in control group, while extracorporeal extended-field intensity-modulated radiotherapy combined with synchronous chemotherapy was adopted in observation group. The treatment was conducted 5 times per week and for 8 weeks, and the patients were followed-up for 3 years. The total effective rate, toxicity reaction, local progression-free survival and survival rate in two groups were compared. Results The total effective rate of observation group was higher than that of control group (88.3% vs 73.3%, P<0.05), while there was no statistical difference in the occurrence rate of toxicity reaction and percentage of stage III-IV between two groups (P>0.05). Compared with control group, observation group achieved a longer progression-free survival and a higher survival rate, with statistical significance (P<0.05). Conclusion Extracorporeal extended-field intensity-modulated radiotherapy for locally advanced cervical cancer is proved to be safe and effective.