Abstract

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Title:: Clinical application of anterior segment optical coherence tomography in the diagnosis and treatment of virus infectious keratitis

Author(s):: SHAN Baiyang; ZHAO Haiyan; Department of Ophthalmology, Liaoyang Central Hospital, Liaoyang 111000, China

Keywords:: Keywords: anterior segment optical coherence tomography; herpes simplex virus; infectious keratitis; confocal microscope

Abstract:: Abstract: Objective To investigate in vivo corneal changes before and after treatment in early-stage herpes simplex keratitis (HSK) using anterior segment optical coherence tomography (AS-OCT) so as to provide a reasonable basis for clinical diagnosis and treatment. Methods Three patients with keratitis were enrolled in the study. Confocal microscope and AS-OCT were used to observe corneal changes of 3 patients before and after being treated with certain medications. Results Based on the highly reflective bands in the corneal stroma displayed by AS-OCT, the high-resolution images of suspected HSK in all patients were successfully obtained. The depths and widths of the highly reflective bands varied from case to case. Some bands ran obliquely from the deep peripheral stroma toward the anterior stroma, and some were located at different depths and ran relatively parallel to the corneal layers. Compared with confocal microscope, AS-OCT was more suitable for the width and depth measurements of corneal stromal opacity. Conclusion AS-OCT provides a useful auxiliary method for the early diagnosis and treatment of HSK.