Dosimetric analysis of photon optimization algorithm in postoperative intensity-modulated
radiotherapy for cervical cancer(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2019年第7期
- Page:
- 765-769
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Dosimetric analysis of photon optimization algorithm in postoperative intensity-modulated
radiotherapy for cervical cancer
- Author(s):
- LIU Zhibin; SHI Jinping; ZHANG Liwen; XIE Qiuying; TENG Jianjian; LI Yinghui
- Department of Radiation Oncology, Cancer Center, the First People’s Hospital of Foshan (Affiliated Foshan Hospital of Sun Yat-sen
University), Foshan 528000, China
- Keywords:
- Keywords: cervical cancer; intensity-modulated radiotherapy; photon optimization algorithm; dose volume optimization algorithm;
dosimetric analysis
- PACS:
- R730.55；R737.33
- DOI:
- DOI:10.3969/j.issn.1005-202X.2019.07.005
- Abstract:
- Abstract: Objective To explore the dosimetric differences between photon optimization (PO) algorithm and conventional dose
volume optimization (DVO) algorithm in postoperative intensity-modulated radiotherapy (IMRT) for cervical cancer. Methods
Twenty patients who received postoperative IMRT for cervical cancer were enrolled in this study. After target areas and organsat-
risk were delineated, two kinds of IMRT plans, namely PO plan and DVO plan, were designed based on PO algorithm and
DVO algorithm, separately. The dosimetric characteristics, passing rate and treatment efficiency of the two kinds of treatment
plans were evaluated. Results No significant difference was found in the D98%, target coverage and homogeneity index of planning
target volume (PTV). However, compared with those in DVO plan, the D2% and Dmean of PTV were lower in PO plan (P=0.019,
0.016), and the conformity index (CI) of PTV was better in PO plan (P=0.005). The V30 of bladder and V20 of left femoral head
in PO plan were lower than those in DVO plan (P=0.000, 0009), while the V15 of small intestine, V30 of rectum and V30 of left and
right femoral heads in PO plan were higher than those in PO plan (P=0.000, 0.001, 0.000, 0.000). Compared with DVO plan,
PO plan had a lower dose exposure in the V30 of normal tissues (P=0.005) and higher dose exposures in the V5 and V10 of normal
tissue (P=0.000, 0.000). The passing rates of two kinds of plans met treatment requirements, and the passing rate of PO plan
were (98.06±0.81)%, higher than (96.05±1.09)% of DVO plan. Compared with those of DVO plan, the monitor units in PO plan
was decreased by an average of 10.7%; the treatment time was reduced by an average of 10.5%; and the optimization time was
shortened by an average of 35.4%. Conclusion Both PO plan and DVO plan can satisfy clinical requirements. The application
of PO algorithm in IMRT plan for cervical cancer which has advantages in the target dose distribution can improve the target conformity, reduce monitor units, shorten planning time and treatment time, and achieve a more accurate dose exposure.
Keywords: cervical cancer; intensity-modulated radiotherapy; photon optimization algorithm; dose volume optimization algorithm;
Last Update: 2019-07-24