Predictive analysis on ventricular tachyarrhythmia using two entropy measures of short-term heart rate variability signals(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2019年第10期
- Page:
- 1217-1227
- Research Field:
- 医学信号处理与医学仪器
- Publishing date:
Info
- Title:
- Predictive analysis on ventricular tachyarrhythmia using two entropy measures of short-term heart rate variability signals
- Author(s):
- DONG Hongsheng; LIU Qing; LIN Juan; SU Fang
- Department of Electrical Engineering, Lanzhou Institute of Technology, Lanzhou 730050, China
- Keywords:
- ; ventricular tachyarrhythmia; heart rate variability; sample entropy; point by point multi-scale entropy; complexity
- PACS:
- R318
- DOI:
- DOI:10.3969/j.issn.1005-202X.2019.10.020
- Abstract:
- Objective The ventricular tachyarrhythmia including sustained ventricular tachycardia (VT) and ventricular fibrillation (VF) is the major precipitating factor of sudden cardiac death. Whether there is significant change in the heart rate variability (HRV) preceding the onset of VT/VF events can be tested and the results can be served as the early warning signs of VT or VF. Methods A total of 135 samples consisted of heart rate variability signals preceding the onset of VT/VF events (VT/VF series) and normal sinus rhythm (CON series) from the same patient were taken as test series, and these samples were recorded by implantable cardioverter defibrillators (ICD) in 78 patients. The interferences such as artifacts and ectopic beats in test series were removed by signal pre-processing, and two nonlinear complexity measures based on sample entropy and point by point multi-scale entropy (PPMSE) were used for complexity analysis on VT/VF series with more than 10 minutes preceding the onset of VT/VF events, and VT/VF series of increased or decreased heart rates preceding the onset of VT/VF events. The complexity of VT/VF series when gradually approaching VT/VF occurrence was also discussed based on PPMSE multi-scale entropy method. Results Compared with that of CON series, in some range of matching tolerance, the sample entropy of HRV preceding the onset of VT/VF events was significantly decreased (r<0.25×SD, P<0.000 5), and the decrease was more obvious for VT or VF series of increased heart rate (r<0.3×SD, P<0.000 1). The decrease of PPMSE of VT/VF series were more significant when gradually approaching VT/VF occurrence, and there was significant difference for the extracted CI value (such as for scale range of 1-30 and N=986, 500, 250, the P value was 1.5×10-2, 4.3×10-3, 1.3×10-5, respectively), and the differentiation for VT/VF series of increased heart rates was even better. Conclusion The spontaneous occurrence of ventricular tachyarrhythmia is not a sudden phenomenon, and there may be some physiological signs before the onset. The two entropy measures might be the suitable nonlinear parameters for the short-term prediction of life-threatening ventricular tachyarrhythmia.
Last Update: 2019-10-30