Abstract

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Title:: Effect of in vitro tissue acoustic properties on dose prediction of high intensity focused ultrasound

Author(s):: LIU Huan; LIU Jihui; LI Faqi; LIU Yalu; GUO Chengbin; School of Biomedical Engineering of Chongqing Medical University/State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology/Chongqing Collaborative Innovation Center for Minimally-invasive and Noninvasive Medicine, Chongqing 400016, China

Keywords:: ; Keywords: high intensity focused ultrasound; in vitro bovine tissue; sound velocity; sound attenuation; temperature rise

Abstract:: Abstract: At present, using high intensity focused ultrasound (HIFU) for clinical treatment mainly relies on experienced doctors to subjectively determine the irradiation dose. Preoperative dose prediction has always been an urgent problem to be solved. Accurately predicting the change of temperature rise rate and establishing a reliable theoretical model of temperature change could provide some reference for clinicians. Herein the reasons for the change in acoustic characteristics of biological tissues are introduced from two perspectives, namely acoustic velocity and sound attenuation changing with temperature. The relevant data of tissue acoustic characteristics measured by previous experiments are summarized, and the variation models of sound velocity and sound attenuation in in vitro bovine tissue changing with temperature rise are analyzed. The consideration of acoustic characteristics of target tissue in HIFU treatment provides a theoretical basis for the further modification of the theoretical model of HIFU dose prediction.