Booster dose in specific region in static intensity-modulated radiotherapy for cervical cancer: a dosimetric analysis(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2019年第9期
- Page:
- 1018-1022
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Booster dose in specific region in static intensity-modulated radiotherapy for cervical cancer: a dosimetric analysis
- Author(s):
- CHEN Ying; LIU Rujia; JIAO Yang; ZHONG Zhipeng
- Department of Radiation Oncology, Jingmen No.2 People’s Hospital, Jingmen 448000, China
- Keywords:
- ; cervical cancer; booster dose in specific region; static intensity-modulated radiotherapy; dosimetric analysis
- PACS:
- R815.6
- DOI:
- DOI:10.3969/j.issn.1005-202X.2019.09.005
- Abstract:
- Abstract: Objective To compare the dosimetric parameters in static intensity-modulated radiotherapy (IMRT) for cervical cancer before and after booster dose in specific region for evaluating the feasibility of booster dose in specific region in static IMRT for cervical cancer. Methods Ten patients with cervical cancer were enrolled in the study. Two plans with the same prescription dose of 4 500 cGy with or without booster dose in specific region were designed based on CMS XiO 4.80 system. The dosimetric parameter, monitor unit, treatment time and the passing rate in two-dimensional dose verification were analyzed and compared. Results Both of the two plans satisfied target dose requirements and provided a significant sparing of organs-at-risk. There was no significant difference in the D2%, Dmean and D98% of planning target volume (P>0.05). However, the target coverage rate, conformity index and homogeneity index of target areas in plan with booster dose in specific region were superior to those in plan without booster dose in specific region (P<0.05). After booster dose in specific region, the dose volume of organs-at-risk was slightly increased, and statistical significances were only found in the V45 of small intestine, rectum and bladder and the V40 of bilateral femoral heads (P<0.05). After booster dose in specific region, the dosimetric parameters of normal tissues were increased, except for the V15 of normal tissues (P>0.05). Moreover, the comparison between two plans showed that there were statistical significances in monitor units and treatment time (P<0.05), not in the passing rate of two-dimensional dose verification (P>0.05). Conclusion Booster dose in specific region which is conducive to optimizing target coverage rate, and the conformity index and homogeneity index of target areas while the changes to other parameters are acceptable is recommended in the planning of static IMRT for cervical cancer.
Last Update: 2019-09-23