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 Effects of pulsed electromagnetic field stimulation on neuropathic pain in diabetic rats(PDF)

《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]

Issue:
2019年第9期
Page:
1082-1086
Research Field:
医学生物物理
Publishing date:

Info

Title:
 Effects of pulsed electromagnetic field stimulation on neuropathic pain in diabetic rats
Author(s):
 LI Lan YANG Weiwei WANG Nan
 Department of Anesthesiology, Ninth Hospital of Xi’an, Xi’an 710054, China
Keywords:
 Keywords: pulsed electromagnetic field stimulation diabetes neuropathic pain pain threshold nerve conduction velocity
PACS:
R741;R318
DOI:
DOI:10.3969/j.issn.1005-202X.2019.09.017
Abstract:
 Abstract: Objective To investigate the effects of exogenous pulsed electromagnetic field therapy on neuropathic pain in diabetic rats. Methods Thirty male adult SD rats were randomly and equally assigned into blank control (Control), DNP, and diabetic neuropathic pain (DNP) combined with electromagnetic field stimulation (DNP+EMF) groups. DNP animal model was established by the intraperitoneal injection of streptozotocin. The rats in DNP+EMF group were subjected to whole-body electromagnetic field stimulation with 6 h/day (pulse waveform, 15 Hz frequency and 30 Gs intensity). The paw mechanical pain threshold, paw thermal pain threshold, sensory nerve conduction velocity and motor nerve conduction velocity were determined at 0, 2, 4, 6 and 8 weeks after electromagnetic field stimulation. Results At 4, 6 and 8 weeks after electromagnetic field stimulation, the rats in DNP+EMF group exhibited much higher paw mechanical pain threshold and paw thermal pain threshold than those in DNP group (P<0.05). Pulse electromagnetic field stimulation significantly increased the sensory nerve conduction velocity in DNP rats from 2 weeks after electromagnetic field stimulation (P<0.05), and also significantly increased the motor nerve conduction velocity in DNP rats from 4 weeks after electromagnetic field stimulation (P<0.05). Conclusion Exogenous pulsed electromagnetic field stimulation is able to significantly improve the neuropathic pain symptoms in diabetic rats as evidenced by increased pain sensitivity and nerve conduction velocity. Pulsed electromagnetic field stimulation is expected to become a novel biophysical strategy for the treatment of DNP in clinic.

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Last Update: 2019-09-24