Abnormal functional connectivity in frontoparietal network in primary insomnia patients(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第8期
- Page:
- 988-992
- Research Field:
- 脑科学与神经物理
- Publishing date:
Info
- Title:
- Abnormal functional connectivity in frontoparietal network in primary insomnia patients
- Author(s):
- XU Guang1; WU Hong1; JIANG Guihua2; MA Xiaofen2
- 1. Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou 510317, China; 2. Department of Radiology, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
- Keywords:
- ; Keywords: primary insomnia; resting-state functional magnetic resonance imaging; resting-state network; frontoparietal network; independent components analysis
- PACS:
- R445.2；R740
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.08.023
- Abstract:
- Abstract: Objective To investigate the abnormal functional connectivity in patients with primary insomnia via functional magnetic resonance imaging (fMRI) technology and discuss its relationships with the disease duration and clinical features of primary insomnia. Methods Forty patients with primary insomnia and 35 age-, gender- and education-matched healthy controls were selected to undergo a resting-state fMRI scan. Independent component analysis was used to identify 10 resting-state networks from resting-state fMRI data. FSL randomise non-parametric permutation test was used to carry out dual regression analysis for testing the voxel-based differences in 10 resting-state networks between two groups. Relationships between the abnormal functional connectivity and the clinical variables were investigated with Pearson correlation analysis. Results In the resting state, compared with normal controls, patients with primary insomnia showed that the superior parietal lobule and superior frontal gyrus in the right frontoparietal network had decreased functional connectivity with other brain regions in the network. Moreover, no significant correlations between abnormal functional connectivity and clinical indicators were found in patients with primary insomnia. Conclusion In the resting state, patients with primary insomnia are characterized by abnormal right frontoparietal network connectivity, and the finding in this study is conducive to the understanding of neural activity in patients with primary insomnia.
Last Update: 2018-07-26