Evaluation of the early therapeutic effect of radiotherapy and chemotherapy for advanced esophageal squamous cell carcinoma by 3.0T MR diffusion weighted imaging(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第12期
- Page:
- 1452-1456
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Evaluation of the early therapeutic effect of radiotherapy and chemotherapy for advanced esophageal squamous cell carcinoma by 3.0T MR diffusion weighted imaging
- Author(s):
- SU Baoan; XU Zhichen; LI Aien
- Department of Radiotherapy, the First People’s Hospital of Quanzhou City, Quanzhou 362000, China
- Keywords:
- ; Keywords: magnetic resonance; diffusion-weighted imaging; esophageal squamous carcinoma/drug therapy; esophageal squamous carcinoma/radiotherapy; early therapeutic effect
- PACS:
- R445.2；R735.1
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.12.016
- Abstract:
- Abstract: Objective To investigate the value of 3.0T magnetic resonance (MR) diffusion weighted imaging (DWI) in evaluating the early therapeutic effect of radiotherapy and chemotherapy for advanced esophageal squamous cell carcinoma. Methods A total of 53 patients with advanced esophageal cancer who were scheduled for radical radiotherapy and chemotherapy in the First People’s Hospital of Quanzhou City from June 2016 to December 2017 were selected. Routine plain MR scan and DWI examination were performed at different time points before and after treatment. According to the short-term therapeutic effect, the patients were assigned into effective group and ineffective group. The changes of apparent diffusion coefficient (ADC) values, △ADC and the maximum diameter of the tumor before and after treatment were compared between two groups. The change rate of ADC value in evaluation of early therapeutic effect of radiotherapy and chemotherapy for esophageal cancer was analyzed by receiver operating characteristic curve (ROC) curve. Results Forty-one cases were assigned into effective group and 12 cases in ineffective group. ADC values of effective group and ineffective group gradually increased after 1 week of treatment, after 2 weeks of treatment and at the end of treatment (P<0.05), and △ADC was significantly higher in effective group than in ineffective group at above time points (P<0.05). There was no significant differences of the maximum diameter of the tumor in two groups before treatment and after 1 week of treatment (P>0.05), but the diameter was significantly decreased after 2 weeks of treatment and at the end of treatment (P<0.05). ROC curve analysis showed that the area under ROC curve was the largest after 1 week of treatment (0.785). With the change rate of ADC at this time point (15.5%) as the threshold, the sensitivity, specificity, positive predictive value and negative predictive value for evaluating the short-term therapeutic effect of radiotherapy and chemotherapy were 86.5%, 69.8%, 89.4% and 63.4%, respectively. Conclusion MR-DWI is of great value in evaluating the early therapeutic effect of radiotherapy and chemotherapy for esophageal squamous cell carcinoma. The change rate of ADC value after 1 week of treatment can be used as the optimal time point for predicting the therapeutic effect.
Last Update: 2018-12-26