Abstract

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Title:: Experimental research of early detection of cerebral hemorrhage in closed craniocerebral injury based on magnetic induction

Author(s):: YANG Jun; ZHANG Haisheng; JIN Gui; CHEN Mingsheng; QIN Mingxin; College of Biomedical Engineering and Medical Imaging, Army Military Medical University, Chongqing 400038, China

Keywords:: closed cerebral hemorrhage; magnetic induction phase shift; non-contact; noninvasive; impact

Abstract:: Objective To establish a magnetic induction phase shift (MIPS)-based system for early, non-contact and noninvasive detection of closed cerebral hemorrhage (CCH), and to determine whether the rabbit has CCH utilizing the relationship between MIPS and electrical conductivity of the brain tissues. Methods Impact injury on the parietal bone in rabbits was caused by an impactor. In 1 hour after injury, CT scan was performed on the head of rabbits. At 8 hours after injury, the brain was taken out for pathological section HE staining to verify the existence of CCH after injury in rabbits. Finally, the homemade MIPS detection system was used to collect the MIPS signals in the rabbits before injury and within 0 to 10 minutes after injury. The obtained MIPS signals were then processed and analyzed. Results In the animal model, the results of CT and pathological experiment verified the existence of CCH after impact injury in rabbits. In the detection experiment, the change of MIPS before and after injury in rabbits was (27.168 76+6.582 64)° at the characteristic frequency. Moreover, with the development of the condition after injury, the trend of MIPS appeared a tiny drop first and then slowly rising. Conclusion In the early stage, MIPS system can not only differentiate rabbits with CCH during the test, but also reflect the change of CCH better.