Abstract: Objective To observe the effect of different repair materials for esthetic restoration of anterior teeth and its long-term follow-up outcomes. Methods A total of 80 patients undergoing esthetic restoration of anterior teeth were selected for prospective study. The selected patients were divided into group A (40 cases, 58 teeth) and group B (40 cases, 62 teeth) by random number table. In group A, 3M-Z350 nanocomposite resin was applied for esthetic restoration, while in group B, 3M-Z100 composite resin was adopted. At 1 day, 1 week, 1 month, 3 months after operation, the incidences of dental hypersensitiveness and pain which was assessed by visual analogue scale (VAS) were compared between two groups. Moreover, after 3-year follow-up, the degrees of marginal adaptation, color matching and integrity were compared. Results The incidence of dental hypersensitiveness in group A at 1 day, 1 week and 1 month after operation were 8.62%, 5.17% and 3.45%, respectively, significantly lower than 22.58%, 17.74% and 14.52% in group B (P<0.05). The incidence of dental hypersensitiveness in group A and group B at 3 months after operation was 6.91% and 16.13%, with no significant differences (P>0.05). The VAS scores in group A at 1 day, 1 week and 1 month after operation were 2.51±0.54, 2.03±0.47 and 1.58±0.38, respectively, significantly lower than 2.72±0.59, 2.35±0.50 and 1.81±0.42 in group B (P<0.05). The VAS scores in the two groups after 3 months of operation had no statistical significance (P>0.05). After 3-year follow-up, two groups didn’t show any significant differences in integrity degree (P>0.05), however, group A was superior to group B in the degrees of marginal adaptation and color matching (P<0.05). Conclusion 3M-Z350 nanocomposite resin for esthetic restoration of anterior teeth achieves a lower incidence of postoperative dental hypersensitiveness as compared with 3M-Z100 composite resin, and is worthy of promotion for it has advantages of less pain and better long-term follow-up outcomes of good marginal adaptation and color matching.