Abstract

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Author(s):: MIAO Hongtao1; MA Shijing2; QUAN Hong1; XIE Conghua2; 1. School of Physics and Technology, Wuhan University, Wuhan 430072, China; 2. Department of Radiation Oncology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China

Keywords:: ; FePt/GO nanocomposites; radiosensitization; cytotoxicity; chemoradiotherapy

Abstract:: Abstract: Objective To explore the potential anticancer effect of FePt/graphene oxide (FePt/GO) nanocomposites in lung cancer. Methods FePt nanoparticles with particle size of about 3 nm were prepared by a chemical reduction method, and FePt/GO nanocomposites were facilely produced by assembling FePt nanoparticles to the surface of GO through sonicate. Transmission electron microscope, atom force microscope and X-ray photoelectron spectroscopy were utilized to characterize the surface morphology and chemical composition of FePt/GO nanocomposites. The obtained FePt/GO nanocomposites were cultured with non small cell lung cancer cells (H1975 cells) and Human embryonic lung fibroblasts (HELF cells), separately, and the cytotoxicity of FePt/GO nanocomposites was evaluated in H1975 cells and HELF cells by CCK-8 assay. The radiosensitization ability of FePt/GO nanocomposites was determined by colony formation test and CCK-8 assay. Results FePt/GO nanocomposites were successfully prepared in this study. Within a certain concentration range, FePt/GO nanocomposites showed significant toxicity to H1975 cells, while keeping no obvious toxicity to HELF cells. Furthermore, FePt/GO nanocomposites enhanced the suppression of X-ray on H1975 cells growth. Conclusion FePt/GO nanocomposite is a potential anticancer agent which could be used in clinical treatment.