Abstract

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Title:: Altered fractional amplitude of low-frequency fluctuation of fMRI signals and its correlation with cognitive impairment in type 2 diabetes mellitus patients

Author(s):: WANG Weiqian1; LIU Xinfeng2; CAO Weifang1; XUE Yazhuo3; GUO Yancheng3; LU Aixia3; CUI Dong1; GUO Yongxin1; JIAO Qing1; 1. School of Radiology, Taishan Medical University, Tai’an 271016, China; 2. Taishan Sanatorium of Shandong Province, Tai’an 271000, China; 3. School of Nursing, Taishan Medical University, Tai’an 271016, China

Keywords:: ; type 2 diabetes mellitus; functional magnetic resonance imaging; fractional amplitude of low-frequency fluctuation; cognitive impairment

Abstract:: Objective To investigate abnormal resting-state brain activities in patients with type 2 diabetes mellitus (T2DM) by functional magnetic resonance imaging (fMRI) technology and cognitive function tests. Methods The fMRI signals and cognitive functions of 28 T2DM patients and 28 healthy controls were collected. Fractional amplitudes of low-frequency fluctuation (fALFF) of fMRI signals were calculated, and differences of fALFF between the two groups were compared. Correlations between results of fALFF and cognitive tests were analyzed. Results Compared with healthy controls, T2DM patients developed significantly increased fALFF in the right cerebellum and the right dorsolateral superior frontal gyrus, and obviously decreased fALFF in the left middle temporal gyrus, the left calcarine, the right middle temporal gyrus and the right supplementary motor area. fALFF in the right middle temporal was negatively correlated to the results of trail making test-A. Conclusion Abnormal spontaneous neural activities are observed in T2DM patients, which may provide preliminary imaging evidence for cognitive impairment in diabetic patients.