Application research on Auto-planning in non-coplanar VMAT plan for brain gliomas(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第5期
- Page:
- 514-518
- Research Field:
- 医学放射物理
- Publishing date:
Info
- Title:
- Application research on Auto-planning in non-coplanar VMAT plan for brain gliomas
- Author(s):
- ZHANG Guoqian1; ZHANG Shuxu1; WANG Ruihao1; LEI Huaiyu1; LI Wanzhen2; LIAO Boyu2
- 1. Department of Radiotherapy, Cancer Center of Guangzhou Medical University, Guangzhou 510095, China; 2. Graduate School, Guangzhou Medical University, Guangzhou 510182, China
- Keywords:
- ; gliomas; Auto-planning; non-coplanar volumetric modulated arc therapy; manual volumetric modulated arc therapy plan
- PACS:
- R737.33；R730.55
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.05.004
- Abstract:
- Objective To discuss the feasibility of Auto-planning based non-coplanar volumetric modulated arc therapy (AP-VMAT) plan for glioma by comparing AP-VMAT plan and conventional manual volumetric modulated arc therapy (M-VMAT) plan in terms of the dosimetric differences of planning target volume (PTV) and organs-at-risk (OAR). Methods From February 15 to December 18, 2016, 8 glioma patients receiving treatment in Cancer Center of Guangzhou Medical University were selected for CT-simulation based localization and segmentation of PTV and OAR. Non-coplanar M-VMAT plan and AP-VMAT plan were designed for the same set of CT images with the use of Pinnacle 9.10 treatment planning system. The target coverage (D95), homogeneity index and conformity index of PTV, and OAR dose were compared between M-VMAT plan and AP-VMAT plan. Results The comparison between AP-VMAT plan and M-VMAT plan didn’t showed any statistical differences in D95, mean dose (Dmean) and homogeneity index (P>0.05). The conformity index in AP-VMAT plan was better than that in M-VMAT plan ［(0.890±0.046) vs (0.750±0.046), P<0.001］. No significant differences between the two plans was found in the maximum dose and D5 of brainstem, the maximum dose and Dmean of ipsilateral eyeball, lens and optic nerve (P>0.05). However, the Dmean of brainstem and the dosimetric parameters of contralateral eyeball, lens, optic nerve and normal tissues were less in AP-VMAT plan as compared with M-VMAT plan (P<0.05). Conclusion Compared with M-VMAT plan, non-coplanar AP-VMAT plan simplify the design process and improve the target conformity and OAR sparing.
Last Update: 2018-05-22