Clinical efficacy and safety of low dose tirofiban hydrochloride combined with emergency coronary intervention in patients with myocardial infarction(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2017年第12期
- Page:
- 1241-1245
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Clinical efficacy and safety of low dose tirofiban hydrochloride combined with emergency coronary intervention in patients with myocardial infarction
- Author(s):
- LEI Xiaochun; QIU Junjie; WANG Xihui
- Department of Cardiology, the Second Affiliated Hospital of Xi’an Medical University, Xi’an 710038, China
- Keywords:
- ; Keywords: tirofiban hydrochloride; emergency coronary; intervention; myocardial infarction; clinical efficacy; safety
- PACS:
- R542.22
- DOI:
- DOI:10.3969/j.issn.1005-202X.2017.12.010
- Abstract:
- Abstract: Objective To analyze the clinical efficacy and safety of low dose tirofiban hydrochloride combined with emergency coronary intervention in patients with myocardial infarction, and to provide reference data for the treatment of patients with myocardial infarction. Methods Admitted to the Second Affiliated Hospital of Xi’an Medical University between October 2013 and October 2016, 110 patients with myocardial infarction were randomly divided into experimental group and control group, with 55 patients in each group. The patients in experimental group were treated with low dose tirofiban hydrochloride combined with emergency coronary intervention, while those in control group received emergency coronary intervention therapy combined with conventional dose tirofiban hydrochloride. SPSS 20.0 statistical software was used to analyze the time between onset and intervention, the occurrence of cardiovascular diseases, the incidence of bleeding complications and the thrombolysis in myocardial infarction (TIMI) blood flow before and after emergency coronary intervention. Results No significant differences were found between two groups in the time between onset and intervention (P>0.05). The incidence of cardiovascular disease in experimental group was 0.00% (0/55) as compared with 7.28% (4/55) in control group, with statistical differences (P<0.05). Before emergency coronary intervention, the comparison between two groups showed significant differences in TIMI grade 0 and 1 (P<0.05), but not in TIMI grade 2 and 3 (P>0.05). After emergency coronary intervention, two groups had significant differences in TIMI grade 0-2 and 3 (P<0.05). Conclusion Low dose tirofiban hydrochloride combined with emergency coronary intervention in patients with myocardial infarction has significant clinical efficacy and high safety.
Last Update: 2017-12-21