Regional homogeneity in euthymic patients with pediatric bipolar disorder: a resting-state functional magnetic resonance imaging study(PDF)
《中国医学物理学杂志》[ISSN:1005-202X/CN:44-1351/R]
- Issue:
- 2018年第1期
- Page:
- 47-53
- Research Field:
- 医学影像物理
- Publishing date:
Info
- Title:
- Regional homogeneity in euthymic patients with pediatric bipolar disorder: a resting-state functional magnetic resonance imaging study
- Author(s):
- CHEN Haoran1; GAO Weijia2; JIAO Qing1; CUI Dong1; XU Qiang4; CAO Weifang1; GUO Yongxin1; LU Dali3; XIAO Qian3; SU Linyan3; LU Guangming4
-
1. School of Radiology, Taishan Medical University, Tai’an 271016, China; 2. Department of Child Psychology, Children’s Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou 310003, China; 3. Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha 410011, China; 4. Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China
- Keywords:
- ; Keywords: functional magnetic resonance imaging; regional homogeneity; pediatric bipolar disorder; cognitive function
- PACS:
- R445.2
- DOI:
- DOI:10.3969/j.issn.1005-202X.2018.01.010
- Abstract:
- Abstract: Objective To investigate the homogeneity of resting-state neuronal activity in euthymic patients with pediatric bipolar disorder (PBD) and analyze the relationship between neuronal activity and cognitive function. Methods Eighteen euthymic patients with PBD and 18 age- and gender-matched healthy controls were enrolled in this study. All the participants underwent functional magnetic resonance imaging (fMRI) scanning, clinical examination and cognitive function tests. The fMRI data were collected to calculate regional homogeneity (ReHo) values, and the association of ReHo values with the results of cognitive function tests and clinical findings were analyzed. Results Compared with healthy control subjects, the patients with PBD showed significantly decreased Stroop color-word test scores and significantly increased ReHo values in the brain regions including the right cerebellum, left inferior frontal gyrus (IFG), and right posterior cingulate cortex (PCC) but decreased ReHo values in the left superior parietal gyrus (SPG) and left supplementary motor area (SMA). ReHo value in the left IFG was negatively correlated with the age of disease onset and Stroop color-word test scores, and positively with the results of trail making test. ReHo value in the right PCC was negatively correlated while the value in the left SMA was positively correlated with the age of PBD onset. Conclusion Euthymic patients with PBD present with altered ReHo of neuronal activity in the brain regions including the cerebellum, IFG, PCC, the SPG and SMA. The dysfunction of the left IFG is related with cognitive impairment and age of disease onset in patients with PBD.
Last Update: 2018-01-25